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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 89364-31-8, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 89364-31-8, Name is Tetrahydrofuran-3-carboxylic acid, molecular formula is C5H8O3
The heterospirocyclic N-methyl-N-phenyl-5-oxa-1-azaspiro[2.4]hept-1-e n-2-amine (6) and N-(5-oxa-1-azaspiro[2.4]hept-1-en-2-yl)-(S)-proline methyl ester (7) were synthesized from the corresponding heterocyclic thiocarboxamides 12 and 10, respectively, by consecutive treatment with COCl2, 1,4-diazabicyclo[2.2.2]octane, and NaN3 (Schemes 1 and 2). The reaction of these 2H-azirin-3-amines with thiobenzoic and benzoic acid gave the racemic benzamides 13 and 14, and the diastereoisomeric mixtures of the N-benzoyl dipeptides 15 and 16, respectively (Scheme 3). The latter were separated chromatographically. The configurations and solid-state conformations of all six henzamides were determined by X-ray crystallography. With the aim of examining the use of the new synthons in peptide synthesis the reactions of 7 with Z-Leu-Aib-OH to yield a tetrapeptide 17 (Scheme 4), and of 6 with Z-Ala-OH to give a dipeptide 18 (Scheme 5) were performed. The resulting diastereoisomers were separated by means of MPLC or HPLC. NMR Studies of the solvent dependence of the chemical shifts of the NH resonances indicate the presence of an intramolecular H-bond in 17. The dipeptides (S,R)-18 and (S,S)-18 were deprotected at the N-terminus and were converted to the crystalline derivatives (S,R)-19 and (S,S)-19, respectively, by reaction with 4-bromobenzoyl chloride (Scheme 5). Selective hydrolysis of (SR)-18 and (S.S)-18 gave the dipeptide acids (R,S)-20 and (SS)-20, respectively. Coupling of a diastereoisomeric mixture of 20 with H-Phe-O?Bu led to the tripeptides 21 (Scheme 5). X-Ray crystal-structure determinations of (S,R)-19 and (S,S)-19 allowed the determination of the absolute configurations of all diastereoisomers isolated in this series.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem