In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 453-20-3, name is 3-Hydroxytetrahydrofuran, introducing its new discovery. Formula: C4H8O2
Open chain unsaturated alcohols 1, having the general formula R1R2C=CH(CH2)CR1R2OH (where R1, R2 = H or CH3, and n = 1-3) and carbocyclic unsaturated alcohols of similar type have been efficiently cyclized to the corresponding hydroxytetrahydrofuran or hydroxytetrahydropyran over titanium silicate molecular sieves (TS-1 and Ti-beta), in one pot under mild liquid phase reaction conditions using dilute hydrogen peroxide as oxidant. When the hydroxy nucleophile may attack either of the activated carbon atoms of the epoxides generated in situ, to lead to a derivative of tetrahydrofuran or tetrahydropyran, the former exclusively formed. The regioselectively for such reaction is 100%. When R1 or R2 = CH3, among the diasteroisomeric products trans predominates over cis. In this cyclization reaction titanium silicate epoxidizes the olefin and successively catalyzes the opening of the oxirane ring via intramolecular attack of hydroxy oxygen. Thus the behavior of titanium sites is bifunctional in nature. However, for bicyclic unsaturated alcohols, because of geometric restriction, activity of medium pore TS-1 is very low. Ti-beta synthesized by dry gel conversion has been found to be an efficient catalyst in oxidative cyclization of such bulky organic substrates as alpha-terpineol, isopulegol, and trans-p-menth-6-ene-2,8-diol to their corresponding tetrahydrofuranols or tetrahydropyranols with a very high regioselectivity.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 453-20-3, and how the biochemistry of the body works.Formula: C4H8O2
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem