Discovery of 3-Methyldihydrofuran-2(3H)-one

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Electric Literature of 1679-47-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1679-47-6, molcular formula is C5H8O2, introducing its new discovery.

(Chemical Equation Presented) An eight-step synthesis of (±)-grandisol features a key sequence involving a high-yielding, microwave-assisted enyne metathesis to yield a 1-alkenylcyclobutene that is semihydrogenated to yield a silyl-protected grandisol. Metathesis catalyst screens revealed an intriguing trend whereby substrate conversion correlated strongly with the identity of the ligands on the catalyst. In addition, new reactivity of 1-alkenylcyclobutenes toward hydrogenation is described.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about (Tetrahydrofuran-3-yl)methanol

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Synthetic Route of 15833-61-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol, molecular formula is C5H10O2. In a Article,once mentioned of 15833-61-1

The 13C NMR spectra of diastereomeric pairs of the title compounds together with some tetrahydrofurans were examined and the chemical shifts were compared with those for the corresponding bicyclo<2.2.1>heptanes and -heptenes.The intramolecular interaction between the n-orbital of an oxygen atom and the ?-orbital of an olefinic bond was found in 2-methylene-7-oxabicyclo<2.2.1>heptane.Intramolecular hydrogen bonding between the 7-oxygen and the hydroxyl group occurs in exo-7-oxabicyclo<2.2.1>heptane-2-methanol.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some scientific research about Dihydrofuran-3(2H)-one

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22929-52-8, Name is Dihydrofuran-3(2H)-one, belongs to tetrahydrofurans compound, is a common compound. Product Details of 22929-52-8In an article, once mentioned the new application about 22929-52-8.

N-Alkylation of indoles is one of the important pathways for the construction of various biologically active indole molecules. Using ketones as N-alkylation reagent for indoles has been a great challenge not only because of the competing alkylation reaction of C-3 position but also because of the poor nucleophilicity of the nitrogen atom of indole, in addition to the steric hindrance and lower electrophilicity of the ketones. A dearomatization-rearomatization strategy has been developed for reductive cross-coupling of indoles with ketones in water. Various functional groups and other heterocyclic compounds are tolerated.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Properties and Exciting Facts About Dihydrofuran-3(2H)-one

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Electric Literature of 22929-52-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 22929-52-8, molcular formula is C4H6O2, introducing its new discovery.

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1,R2. R3, R4, R5, R6, A and B are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 3-Hydroxytetrahydrofuran

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Reference of 453-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2. In a Chapter,once mentioned of 453-20-3

The goal for catalyst development, both homogeneous and heterogeneous, using bio-based feedstocks is designing new and robust materials for the dehydration, decarboxylation, decarbonylation, hydrogenolysis, esterification, and ketonization reactions that are required for converting these renewable, generally oxygenated feedstocks to desirable and renewable products. This chapter summarizes the work done on developing bio-based products in the last decade using the seminal US Department of Energy report on the top twelve bio-based chemicals as a starting point to assess catalyst improvement, novel process options, commercialization potential, and market penetration when possible.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Top Picks: new discover of 3-Hydroxytetrahydrofuran

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 453-20-3, name is 3-Hydroxytetrahydrofuran, introducing its new discovery. name: 3-Hydroxytetrahydrofuran

An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: STR1 wherein the group represented by STR2 is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, naphthyl, tetrahydronaphthyl and indanyl; X is a single bond, an oxygen atom, a sulfur atom or a carbonyl group; and Y is a saturated or unsaturated 5-or 6-membered heterocyclic moiety or cyclic hydrocarbon moiety optionally having a substituent group, an amino group optionally having a substituent group or an aminoalkyl group optionally having a substituent group.

The inventive compound has a high anticoagulant capacity based on its excellent FXa inhibition activity.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Top Picks: new discover of Dihydrofuran-3(2H)-one

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Application of 22929-52-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.22929-52-8, Name is Dihydrofuran-3(2H)-one, molecular formula is C4H6O2. In a Article,once mentioned of 22929-52-8

Preparation of 2,2-disubstituted and 2-monosubstituted alkenylboronic acid esters from aliphatic and aromatic ketones and aldehydes by the boron-Wittig olefination with bis[(pinacolato)boryl]methane was examined and applied on the multigram scale. The influence of the substrate steric and electronic features on the overall efficiency and stereochemical outcome of the reaction was studied. Additionally, a series of diversely functionalized (hetera)cycloalkylidenemethyl and (hetera)cycloalkyl boronic acid-derived building blocks was synthesized.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Archives for Chemistry Experiments of 4971-56-6

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Electric Literature of 4971-56-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Article,once mentioned of 4971-56-6

A new series of novel Podophyllotoxin-like benzo[b]furo[3,4-e][1,4]diazepin-1-ones possessing structural elements of 4-aza-2,3-didehydropodophyllotoxins with central diazepine ring was designed and synthesized as anti-cancer agents. In initial assessment, the cytotoxic activity of the synthesized compounds was evaluated against three cancer cell lines including MCF-7, PC3 and B16-F10 employing the MTT assay. Some of compounds (12h, 13a, 13c and 14b) showed significant cytotoxic activity. So, we investigated the cytotoxicity of compounds 12h, 13a, 13c and 14b, along with podophyllotoxin as the reference drug in different cancer cell lines including A549, A2780, DU145, HeLa, and normal Huvec cell line. Among these four compounds, 13c showed promising antiproliferative activity against all cancer cells stronger than the other compounds and comparable to reference drug podophyllotoxin in some cancer cells. All these four compounds did not show significant cytotoxicity on normal Huvec cell line. The flow cytometry analysis of the MCF-7, PC3 and A2780 human cancer cell lines treated with 13c showed that 13c, induced apoptosis in the MCF-7, PC3 and A2780 human cancer cell lines, which is in good agreement to its cytotoxic activity as well. Compound 13c did not show significant influence on tubulin assembly and exert its cytotoxic effects via induction of apoptosis and has potent and selective cytotoxic effects in cancer cells.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about 1679-47-6

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of 3-Methyldihydrofuran-2(3H)-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1679-47-6, name is 3-Methyldihydrofuran-2(3H)-one. In an article,Which mentioned a new discovery about 1679-47-6

The rhodium-assisted carbonylation of tetrahydrofuran affords three C5-lactones (delta- and gamma-valerolactone, and alpha-methyl-gamma-butyrolactone) and valeric acid under relatively mild conditions.The selectivity of the lactones is excellent in the liquid phase.Depending on the promoting effect of iodine or lithium iodide, the reaction is directed mainly towards either delta-valerolactone or the two methylbutyrolactones.However, the catalytic system induced ionic polymerization of delta-valerolactone, limiting the yield of free lactone considerably.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Archives for Chemistry Experiments of 17347-61-4

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Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 17347-61-4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 17347-61-4

H3R structure-activity relationships for a new class of 4,5-dihydropyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modification of the 4,5-dihydropyridazinone moiety to block in vivo metabolism identified 4,4-dimethyl-6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)- propoxy]-phenyl}-4,5-dihydro-2H-pyridazin-3-one 22 as a lead candidate demonstrating potent in vivo functional H3R antagonism in the rat dipsogenia model and robust wake promoting activity in the rat EEG/EMG model.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem