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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of 2,2-Dimethylsuccinicanhydride, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 17347-61-4, name is 2,2-Dimethylsuccinicanhydride. In an article,Which mentioned a new discovery about 17347-61-4

The invention relates to compounds of formula (I): where A is an optionally substituted heteroaryl, useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about Tetrahydrofuran-3-carboxylic acid

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The invention discloses a method for the selective treatment of glaucoma active ingredients and its related salt preparation method, which belongs to the field of pharmaceutical chemicals. The invention relates to 4 – substituted oxy – 5 – substituted oxy – 2 – methyl benzoic acid, (2 S) – (+) – glycidyl ester substituted sulfonate, 2 – methyl – 2 – nitro-propylamine, tetrahydrofuran – 3 – formic acid, N – (2 – methyl – 2 – nitro-propyl) tetrahydrofuran – 3 – carboxamide, N – (2 – methyl – 2 – amino-propyl) tetrahydrofuran – 3 – carboxamide, (S)- 4, 5 – disubstituted – 2 – methyl benzoic acid ethylene oxide-based methyl ester, 4, 5 – disubstituted – 2 – methyl benzoic acid ((2 S) – 2 – hydroxy – 3 – ((2 – methyl – 1 – (tetrahydrofuran – 3 – carboxamido) c – 2 – yl) ester and its related salt in the at least one compounds as the starting material or intermediates to preparation, can be as high as 77% yield, good reaction selectivity, high purity of the product. (by machine translation)

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome Chemistry Experiments For 3-Hydroxytetrahydrofuran

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Theoretical insights into H-abstraction by ozone from saturated species have been virtually nonexistent, in sharp contrast to the situation for reactions with unsaturated species. Our computed rate constants for reactions with tetrahydrofuran and its methyl derivatives, obtained at various levels of theory, show that abstraction occurs primarily at the carbons situated beside the heterocyclic oxygen, with least likely reaction from the methyl groups. All of the methods tested are in broad relative agreement with this conclusion and with recent experiments although they do differ widely in terms of their absolute values. Abstraction leads variously to the formation of hydrotrioxides, ROOOH, or more directly to R – OH + O2(1Deltag). To understand some of the observed behaviors, dimethyl and diethyl acyclic ethers, methyl and ethyl hydroperoxides, and the alcohols methanol and ethanol were also included in this study. For the simplest system, CH3OH + O3 ? H2C=O + H2O2, an all-electron scalar relativistic CCSD(T)/CBS approach yields a barrier height that differs by >5 kJ mol-1 when an additional multireference treatment up to CCSDT(Q) is considered.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Initial SAR studies on 1-aminomethyl-2-aryl-3-cyano-pyrrolo[1,2-a]pyrimid-7-one-6-carboxylates as human GnRH receptor antagonists were discussed. 2-(2-Methylaminoethyl)pyridine was discovered to be a key feature for generating active compounds. The best compound from the series had 25 nM (Ki) binding affinity to human GnRH receptor.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Can You Really Do Chemisty Experiments About 15833-61-1

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This letter describes the further chemical optimization of VU0424238 (auglurant), an mGlu5 NAM clinical candidate that failed in non-human primate (NHP) 28 day toxicology due to accumulation of a species-specific aldehyde oxidase (AO) metabolite of the pyrimidine head group. Here, we excised the pyrimidine moiety, identified the minimum pharmacophore, and then developed a new series of saturated ether head groups that ablated any AO contribution to metabolism. Putative back-up compounds in this novel series provided increased sp3 character, uniform CYP450-mediated metabolism across species, good functional potency and high CNS penetration. Key to the optimization was a combination of matrix and iterative libraries that allowed rapid surveillance of multiple domains of the allosteric ligand.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Discovery of 87392-07-2

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C5H8O3. Introducing a new discovery about 87392-07-2, Name is (S)-Tetrahydrofuran-2-carboxylic acid

The present invention provides novel compounds of Formula (I), which are CB2 selective ligands useful for the treatment of pain.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome Chemistry Experiments For (S)-4-Hydroxydihydrofuran-2(3H)-one

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In this paper, the rapid liquefaction of a corncob was achieved by plasma electrolysis, providing a new method for cellulosic biomass liquefaction. The liquefaction rate of the corncob was 95% after 5 min with polyethylene glycol and glycerol as the liquefying agent. The experiments not only showed that H+ ions catalyzed the liquefaction of the corncob, but also that using accelerated H+ ions, which were accelerated by an electric field, could effectively improve the liquefaction efficiency. There was an obvious discharge phenomenon, in which the generated radicals efficiently heated the solution and liquefied the biomass, in the process of plasma electrolytic liquefaction. Finally, the optimum parameters of the corncob liquefaction were obtained by experimentation, and the liquefaction products were analyzed.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Final Thoughts on Chemistry for 3-Hydroxytetrahydrofuran

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The general solubility equation (GSE) proposed by Jain and Yalkowsky was used to estimate aqueous solubility of 1026 non-electrolytes. The only parameters used in the GSE are melting points (MP) and octanol-water partition coefficients (Kow). No fitted parameters and no training set are employed in the GSE. The experimental solubility values were taken from the AQUASOL dATAbASE. The average absolute error and the root-mean-square error in the solubility estimates are 0.38 and 0.53 log units, respectively. Thus, with an observed MP and calculated Kow; the users can obtain a reasonable estimation of the aqueous solubility of any organic non-electrolyte.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome Chemistry Experiments For 89364-31-8

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Compounds are disclosed that have a formula represented by the following (I), the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Top Picks: new discover of 4971-56-6

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 4971-56-6, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4971-56-6, name is Furan-2,4(3H,5H)-dione. In an article,Which mentioned a new discovery about 4971-56-6

This work highlights the literature of one of the most valuable moieties in the field of organic chemistry. In this review, the chemistry of tetronic acid as a simple precursor to privileged heterocyclic motifs is described. The synthetic procedures of different fused heterocycles incorporating a furan moiety are described. Fused heterocycles are classified as bicyclic, tricyclic, tetracyclic and spiro-fused pyran derivatives.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem