In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 21461-84-7, name is (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid. In an article，Which mentioned a new discovery about 21461-84-7
(Chemical Equation Presented) From the known lactone (S)-4, easily derived from L-glutamic acid, a scalable approach to chiral building block O-silylated 3-hydroxypiperidin-2-one 3 and alkaloid 1 was achieved in five and six-steps respectively. The key steps are a chemo selective amidation of lactone-ester 5 and a one-pot reductive borane-decomplexation, N-debenzylation and cyclization.
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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem