Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Product Details of 15833-61-1. Introducing a new discovery about 15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol
In the present work we describe the synthesis and the in vitro evaluation of a series of arachidonic acid derivatives of general structure I as endocannabinoid transporter inhibitors. In addition, we report the first in vivo studies of the most potent derivative (4, UCM707) within this series. The majority of compounds studied are highly potent (IC50=24-0.8 muM) and selective endocannabinoid uptake inhibitors with very low affinities for either the enzyme fatty acid amide hydrolase (IC50=30-113 muM) or for cannabinoid receptor subtype 1 (CB1), cannabinoid receptor subtype 2 (CB2) and vanilloid receptor subtype 1 (VR1) (Ki=1000-10000 nM). Among them, (5Z,8Z,11Z,14Z)-N-(fur-3-ylmethyl)icosa-5,8,11,14-tetraenamide (UCM707) behaves as the most potent endocannabinoid transporter inhibitor described to date (IC50=0.8 muM) and exhibits improved potency for the anandamide transporter, high selectivity for CB1 and VR1 receptors, and modest selectivity for CB2. In vivo it enhances the analgesia and hypokinetic effects induced by a subeffective dose of anandamide.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 15833-61-1, you can also check out more blogs about15833-61-1
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem