Awesome and Easy Science Experiments about Oxolane-2-carbonyl chloride

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of Oxolane-2-carbonyl chloride. Introducing a new discovery about 52449-98-6, Name is Oxolane-2-carbonyl chloride

The synthesis of alpha,alpha-disubstituted beta-amino esters and peptide derivatives from readily available 4-spiro-beta-lactams 1 is described. The geminally disubstituted beta-amino esters are obtained from the N-Boc spiro beta-lactams 2 by treatment with potassium cyanide in methanol. Alternatively, the use of spiro beta-lactams 2 as acylating agents of the amino group of C-protected amino acids, allowed its direct incorporation into a peptidic chain.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem