87392-05-0, Name is (R)-(+)-2-Tetrahydrofuroic acid, belongs to tetrahydrofurans compound, is a common compound. Recommanded Product: (R)-(+)-2-Tetrahydrofuroic acidIn an article, once mentioned the new application about 87392-05-0.
Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-Site amyloid precursor protein cleaving enzyme (Bace1) inhibitors
We have previously shown that hydroxyethylamines can be potent inhibitors of the BACE1 enzyme and that the generation of BACE1 inhibitors with CYP 3A4 inhibitory activities in this scaffold affords compounds (e.g., 1) with sufficient bioavailability and pharmacokinetic profiles to reduce central amyloid-beta peptide (Abeta) levels in wild-type rats following oral dosing. In this article, we describe further modifications of the P1-phenyl ring of the hydroxyethylamine series to afford potent, dual BACE1/CYP 3A4 inhibitors which demonstrate improved penetration into the CNS. Several of these compounds caused robust reduction of Abeta levels in rat CSF and brain following oral dosing, and compound 37 exhibited an improved cardiovascular safety profile relative to 1.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 87392-05-0
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem