One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 3-Methyldihydrofuran-2(3H)-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1679-47-6, Name is 3-Methyldihydrofuran-2(3H)-one, molecular formula is C5H8O2
Ester hydrogenation catalyzed by a ruthenium(II) complex bearing an N-heterocyclic carbene tethered with an “nH2” group and a DFT study of the proposed bifunctional mechanism
A ruthenium(II) catalyst containing an NHC-amine (NHC = Nheterocyclic carbene) ligand (C-NH2) catalyzes the H2-hydrogenation of various esters and lactones at 50 C and 25 bar of H2 pressure, mild reaction conditions compared with other reported catalysts. A maximum turnover frequency of 1510 h-1 for the hydrogenation of phthalide with a conversion of 96% is achieved in 4 h. DFT calculations suggest a concerted, asynchronous bifunctional mechanism for homogeneous ester hydrogenation; a proton transfer step from the N-H group of a ruthenium hydride-amine complex to the carbonyl group has the largest energy barrier in the catalytic cycle. A surprising observation is that methyl pivalate ( tBuCOOCH3) is hydrogenated much more rapidly than is tert-butyl acetate (CH3COOtBu). This is explained by the energetics of the rate-determining step of the proposed Ru-H/N-H bifunctional mechanism.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application In Synthesis of 3-Methyldihydrofuran-2(3H)-one, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1679-47-6
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem