Application of 52449-98-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 52449-98-6, molcular formula is C5H7ClO2, introducing its new discovery.
Heterocyclic nonionic X-ray contrast agents V: A facile conversion of 2-tetrahydrofuroamides into alpha-hydroxy-delta-valerolactams and a general synthesis of lactams conjugated to 2,4,6-triiodoisophthalamides
The synthesis of 2,4,6-triiodoisophthalamides substituted by a lactam moiety is described. A tandem ring opening-ring closure methodology consisting of a regiospecific ether cleavage of the tetrahydrofuroanilide 14b, followed by lactamization to alpha-oxygenated anilides 15b or 16b, gave alpha-O-functionalized-delta-valerolactams 12b or 13b, respectively. This approach is also compatible with the presence of ester and carbonyl chloride functions on the triiodophenyl moiety. A general synthesis of lactams 34-39 was also achieved. Further chemical modifications led to water soluble unsubstituted-lactams (34d, 35d, 37d) and alpha-hydroxyl-lactams [42(d,e), 13(d,e) and 43d] that are of interest as X-ray contrast agents.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 52449-98-6 is helpful to your research. Application of 52449-98-6
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem