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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 1679-47-6, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1679-47-6, name is 3-Methyldihydrofuran-2(3H)-one. In an article£¬Which mentioned a new discovery about 1679-47-6
Intramolecular nucleophilic acyl substitution reactions mediated by XTi(O-i-Pr)3 (X = Cl, O-i-Pr)/2i-PrMgBr reagent. Efficient synthesis of functionalized organotitanium compounds from unsaturated compounds
Treatment of acetylenic or olefinic carbonates and esters with a low-valent titanium reagent diisopropoxy(eta2-propene)titanium (1), readily generated by the reaction of Ti(O-i-Pr)4 or ClTi(O-i-Pr)3 with 2i-PtMgX, resulted in an intramolecular nucleophilic acyl substitution (INAS) reaction to afford organotitanium compounds having a carbonyl functional group, in good to excellent yields. Thus, the treatment of alkyl alkynyl carbonates 2 or alkyl alkenyl carbonates 4 with 1 gave organotitanium compounds having a lactone and/or ester group. Similarly, alkyl alkynoates 10 or alkynyl esters 14 of carboxylic acids reacted with 1 to give organotitanium compounds having a cyclic or acyclic ketone group, respectively. Thus, the reaction provides, after hydrolysis, five- or six-membered alpha-alkylidene lactones and/or alpha,beta-unsaturated esters from 2, gamma-butyrolactone derivatives from 4, five- or six-membered alpha-alkylidene cyclic ketones from 10, and acyclic alpha,beta-unsaturated ketones 15 from 14. In all cases, the yields are excellent and the generation of the organotitanium compounds was confirmed by deuterolysis. The organotitaniums 6 and 11c reacted smoothly with iodine to afford 2-(iodomethyl)-4-butanolide (9) and alpha-[iodo(trimethylsilyl)methylidene]cyclopentanone, respectively. The organotitanium compounds obtained here also reacted with aldehydes to give the corresponding adducts, thus opening up a new access to substituted alpha,beta-butenolides from 2, to gamma-butyrolactones from 4, and to the corresponding tetrasubstituted furan from 10 and 14.
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem