Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: Tetrahydrofurans. Introducing a new discovery about 13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione
On the Baylis-Hillman reaction of acrylate, acrylonitrile, and acrolein with some non-enolizable alpha-dicarbonyl compounds: synthesis of phytotoxic bipolaroxin models
The Baylis-Hillman reaction of acrylonitrile, methyl acrylate, and acrolein with several cyclic alpha-dicarbonyl compounds was investigated.Whereas acrylonitrile reacted with most of these ketones, giving good yields of the expected 1′-cyanovinyl carbinols, the more sterically demanding methyl acrylate failed to undergo the reaction.Attempted Baylis-Hillman reaction of acrolein with the 1,2-dicarbonyl substrates usually resulted in polymers but, in two cases, the desired alpha-substituted acroleins were obtained.An alternative route to such compounds was developed, employing a Grignard-allylic oxidation sequence.In bioassays, some of the products, embodying the functionality believed responsible for the phytotoxicity of the sesquiterpene bipolaroxin, inhibited germination of lettuce seeds.This activity diminished with time. – Key words: Baylis-Hillman, acrylonitrile, acrylate, acrolein, alpha-dicarbonyl, bipolaroxin, phytotoxicity.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: Tetrahydrofurans, you can also check out more blogs about13031-04-4
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem