Synthetic Route of 149809-43-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent£¬once mentioned of 149809-43-8
For the preparation of a preparation method of the midbody of posaconazole (by machine translation)
This invention discloses a process for preparing the formula 1 shown in the process for the preparation of posaconazole intermediate compound 1 method. Preparation method of the invention is compound have been reported in the literature for 2 as raw material, first of all three alkyl silicon-based protection of hydroxy to obtain compound 3, then with the triazole sodium salt of 4 reaction, to obtain compound 5, then in toluene sulfonyl chloride and alkali escapes the silicon ether and perform under the action of toluene sulfonyl protection to obtain compound 1. The invention can overcome the disadvantages of the prior art, and does not pass the splitting step, reduced side reaction occurs and impurity appear, improves the reaction selectivity and yield. (by machine translation)
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 149809-43-8. In my other articles, you can also check out more blogs about 149809-43-8
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem