The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C4H4O3, 108-30-5, Name is Dihydrofuran-2,5-dione, SMILES is O=C(CC1)OC1=O, in an article , author is Kang, Houng, once mentioned of 108-30-5.
Nickel-Catalyzed Vinylidene Insertions into O-H Bonds
A (pybox)Ni catalyst (where pybox = pyridine-bis(oxazoline)) promotes the reductive cyclization of beta-hydroxy 1,1-dichloroalkenes to form 2,3-dihydrofurans. The substrates for this reaction are conveniently prepared by an aldol addition, followed by one-carbon homologation. Chiral substrates are accessible in highly enantioenriched form, allowing for the synthesis of stereochemically complex 2,3,4-trisubstituted products. Mechanistic studies support a vinylidene O-H insertion rather than a C-O cross-coupling pathway.
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Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem