Electric Literature of 104-61-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 104-61-0, Name is 5-Pentyldihydrofuran-2(3H)-one, SMILES is O=C1OC(CCCCC)CC1, belongs to tetrahydrofurans compound. In a article, author is Du, Li-Juan, introduce new discover of the category.
Synthesis of 1,6-Dihydropyridine-3-carbonitrile Derivatives via Lewis Acid-Catalyzed Annulation of Propargylic Alcohols with (E)-3-Amino-3-phenylacrylonitriles
A novel Lewis acid-catalyzed, highly efficient, practical, and atom-economical protocol for the synthesis of functionalized 1,2-dihydropyridine-3-carbonitrile derivatives in the presence of Bi(OTI)(3) (10 mol %) in tetrahydrofuran (2.0 mL) at 80 degrees C for 8 h in air is described, starting from readily accessed propargylic alcohols and (E)-3-amino-3-phenylacrylonitriles. This cycloaddition protocol, which is scalable and proceeds under mild conditions, is amenable to the gram-scale construction of valuable 1,2-dihydropyridine-3-carbonitriles. Furthermore, the good functional group compatibility and broad scope of this strategy were demonstrated by a broad range of propargylic alcohols and (E)-3-amino-3-phenylacrylonitriles, with yields ranging from 34 to 96%.
Electric Literature of 104-61-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 104-61-0 is helpful to your research.
Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem