One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 3-Methyldihydrofuran-2(3H)-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1679-47-6, Name is 3-Methyldihydrofuran-2(3H)-one, molecular formula is C5H8O2
A synthesis method of famciclovir impurity C (by machine translation)
The invention discloses a famciclovir impurity C synthetic method. Although the current literature reported famciclovir impurity C of structure and associated liquid phase chromatographic behavior, but did not disclose the method for obtaining the impurity. The invention adopts the following technical solutions: (¡À) – alpha – to methyl – gamma – butyrolactone as raw materials, in the open loop in the acetic acid solution hydrobromide (¡À) obtained – 2 – methyl – 4 – bromo butyric acid, then converted into (¡À) – 2 – methyl – 4 – bromo methyl butyrate, then tetrahydro reduction is alcohol, and acetylation by (¡À) – 2 – methyl – 4 – bromo butyl acetate, then directly with 2 – amino – 6 – chloropurine coupling, to obtain 4 – (2 – amino – 6 – chloro – 9 H – 9 – purinyl) – 2 – methyl butyl acetate, finally subjected to the hydrogenation dechlorination to obtain famciclovir impurity C. The directed synthesis of the present invention each step in the reaction is stable and reliable, total reaction yield is relatively high. (by machine translation)
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem