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Nickela-electrocatalyzed C?H Alkoxylation with Secondary Alcohols: Oxidation-Induced Reductive Elimination at Nickel(III)
Nickela-electrooxidative C?H alkoxylations with challenging secondary alcohols were accomplished in a fully dehydrogenative fashion, thereby avoiding stoichiometric chemical oxidants, with H2 as the only stoichiometric byproduct. The nickela-electrocatalyzed oxygenation proved viable with various (hetero)arenes, including naturally occurring secondary alcohols, without racemization. Detailed mechanistic investigation, including DFT calculations and cyclovoltammetric studies of a well-defined C?H activated nickel(III) intermediate, suggest an oxidation-induced reductive elimination at nickel(III).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 453-20-3, you can also check out more blogs about453-20-3
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem