In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1132878-81-9, name is (3-Aminotetrahydrofuran-3-yl)methanol, introducing its new discovery. Formula: C5H11NO2
Robust and Scalable Approach to 1,3-Disubstituted Pyridylcyclobutanes
An approach to all isomeric 3-pyridylcyclobutane-derived building blocks, i.e. ketones, alcohols and amines, is described. Synthesis of the title compounds relied on the five-step reaction sequence including alkylation of isomeric pyridyl acetonitriles with 1,3-dibromo-2,2-dimethoxypropane. Hydrolysis, decarboxylation and removal of the ketal moiety led to the key 3-pyridylcyclobutanones (obtained on up to 120 g scale in a single run), which were transformed into the corresponding alcohols and amines with high diastereoselectivity. The title cyclobutanone derivatives were used to synthesize three isomeric nicotine analogues, as well as for parallel synthesis of a small lead-like compound library via reductive amination.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1132878-81-9, and how the biochemistry of the body works.Formula: C5H11NO2
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem