Final Thoughts on Chemistry for 4,4-Dimethyldihydrofuran-2,3-dione

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THE DEGRADATION OF CARBOXYLIC ACIDS INTO ALDEHYDES. REGIOSELECTIVE alpha-ACETOXYLATION OF 1,2,4-TRIAZOLIUM SALTS WITH DIACETOXYIODATE(1)ANION

A novel method was developed for degradation of carboxylic acid into aldehydes containing one C atom less whose key step consists in alpha-acetoxylation of 5-alkyl-3-methylthio-1,4-diphenyl-1,2,4-triazolium iodides by (diacetoxyiodo)benzene.The mechanism of the regioselective alpha-acetoxylation was studied and the diacetoxy-iodate(1)anion was shown to be the actual oxidising agent.Further oxidation reactions of tetraethylammonium diacetoxyiodate(1) were investigated.A novel method was developed for the oxidation of primary alkyl amines into aldehydes by the novel heterocyclic reagent 5-bromo-3-methylthio-1,4-diphenyl-1,2,4-triazolium bromide and diethyl azodicarboxylate.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extended knowledge of (cis-Tetrahydrofuran-2,5-diyl)dimethanol

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CHAPTER 6: Renewable Starting Materials, Biocatalysis, and Multicomponent Reactions: A Powerful Trio for the Green Synthesis of Highly Valued Chemicals

This chapter illustrates a series of recent examples on the cooperation of multicomponent reactions with biocatalysis and/or with the use of renewable starting materials derived from biomass. Teaming these three green methodologies affords important benefits from the point of view of sustainable synthesis. In particular, biocatalysts have been used to (i) generate enantiopure inputs for multicomponent reactions, (ii) resolve racemic multicomponent products, and (iii) catalyze the multicomponent process itself. As far as it concerns renewable inputs, this chapter will focus on the exploitation of diols, furan derivatives, levulinic acid, and lipids.

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Tetrahydrofuran – Wikipedia,
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Extended knowledge of 2,2-Dimethylsuccinicanhydride

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 17347-61-4 is helpful to your research. Electric Literature of 17347-61-4

Electric Literature of 17347-61-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 17347-61-4, molcular formula is C6H8O3, introducing its new discovery.

HETEROCYCLIC COMPOUND

The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.

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Tetrahydrofuran – Wikipedia,
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Top Picks: new discover of 1679-47-6

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Synthesis of gamma- and delta-Lactones by Free-Radical Annelation of Se-Phenyl Selenocarbonates

A general method for the synthesis of gamma- and delta-lactones through the intramolecular addition of alkoxycarbonyl radicals, formed by reaction of Se-phenylselenocarbonates with n-Bu3SnH, onto carbon-carbon multiple bonds is described.This free-radical cyclization is characterized by high regioselectivity favoring exo addition and by a high ratio of cyclization to reduction.Monocyclic, fused bicyclic, and spirocyclic lactones are formed in good to excellent yield.Use of allyltri-n-butyltin as a chain-transfer agent in the place of n-Bu3SnH affords the corresponding 3-butenyl lactones.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Discovery of 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one

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New benzylcyclanone derivatives process for preparing them and cosmetic and pharmaceutical compositions containing them

The invention relates to the benzylcyclanone derivatives of formula: STR1 where R1 and R3 denote H, OH, linear or branched C1 -C8 alkyl or linear or branched C1 -C8 alkoxy, R2 and R4 represent H or OH, at least one of the two being OH, R5, R6, R7 and R8 represent H, C1 -C18 alkyl, aralkyl or aryl, it being possible for R5 and R6 and/or R7 and R8 to form an optionally substituted, saturated C5 -C12 ring, X represents O or –(CR9 R10)n with n=1 or 2 and R9 and R10 represent H or CH3 ; if X represents –(CR9 R10)n, R6 and R8, with the atoms of the ring to which they are attached, form a bicyclic system having 7 or 8 carbon atoms; if X represents –(CR9 R10)n with n=1, R9 and R10 =CH3, R5 =H and R6 and R8, with the atoms of the ring to which are attached, form a bicyclic system having 7 carbon atoms, R7 can represent a –CH2 SO3 H residue, optionally in salt form. Process for preparing these compounds and their use as antioxidants and medicinal products for the treatment of skin allergies and inflammations.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 3-Hydroxytetrahydrofuran

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CYCLOALKYLOXY-AND HETEROCYCLOALKYLOXYPYRIDINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR

Certain cycloalkyloxy- and heterocycloalkyloxypyridine compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases

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Tetrahydrofuran – Wikipedia,
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Discovery of 3-Hydroxytetrahydrofuran

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A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus1

The RNA polymerase holoenzyme is a proven target for antibacterial agents. A high-throughput screening program based on this enzyme from Staphylococcus aureus had previously identified a 2-ureidothiophene-3-carboxylate as a low micromolar inhibitor. An investigation of the relationships between the structures of this class of compounds and their inhibitory- and antibacterial activities is described here, leading to a set of potent RNA polymerase inhibitors with antibacterial activity. Characterization of this bioactivity, including studies of the mechanism of action, is provided, highlighting the power of the reverse chemical genetics approach in providing tools to inhibit the bacterial RNA polymerase.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

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Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents

Whole-cell high-throughput screening of the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal chemistry effort. Structure-activity relationship studies followed by pharmacokinetics optimization resulted in the identification of 23 as an attractive lead with good oral bioavailability. Compound 23 was found to be efficacious (ED90 of 28.6 mg¡¤kg-1) in the humanized P. falciparum mouse model of malaria (Pf/SCID model). Representative compounds displayed a moderate to fast killing profile that is comparable to that of chloroquine. This series demonstrates no cross-resistance against a panel of Pf strains with mutations to known antimalarial drugs, thereby suggesting a novel mechanism of action for this chemical class.

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Can You Really Do Chemisty Experiments About 3-Bromotetrahydrofuran

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19311-37-6, Name is 3-Bromotetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. Quality Control of 3-BromotetrahydrofuranIn an article, once mentioned the new application about 19311-37-6.

Process for the preparation of a 3-substituted thio-3-cephem compound

An ester of 7-acylamido-3-acylthio-3- or -2-cephem-4-carboxylic acid represented by general formula (1) STR1 wherein R1 is an acyl group, R2 is a carboxyl-protecting group, R3 is a lower alkyl group, an aryl group or a substituted aryl group, or a mixture of two or more of said ester is used as the starting compound and is reacted wit a tertiary amine and also a secondary amine. Then the tertiary amine salt compound as formed as the reaction product is reacted with a compound of formula (4) wherein R4 is a lower alkyl group, a cycloalkyl group or a heterocyclic group or a heterocyclic group-substituted methyl group and X is a leaving group, whereby the desired ester of 7-acylamido-3-substituted thio-3-cephem-4-carboxylic acid of formula (5) STR2 can be produced preferentially, conveniently and efficiently.

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Tetrahydrofuran – Wikipedia,
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