52449-98-6, Name is Oxolane-2-carbonyl chloride, belongs to Tetrahydrofurans compound, is a common compound. category: TetrahydrofuransIn an article, once mentioned the new application about 52449-98-6.
A process for the preparation of the medicament kuikui zuo lin kind improved process (by machine translation)
The invention relates to a process for the preparation of the medicament kuikui zuo lin kind improved process, to provide a 2 – chloro – 4 – amino – 6, 7 – dimethoxy quinazoline as intermediate synthetic route, in particular comprising the following steps: acrylonitrile with the methylamine is mellow solution is amine reaction to obtain the intermediate (I); in triethylamine as acid benzyl chloride under conditions as protection basal into intermediate (II); the use of metal duplicate hydride reduction to produce intermediate (III); with the tetrahydrofuran chloride in the acylation reaction intermediate (IV); intermediate (IV) under the catalysis of palladium hydrogenolysis reaction occurs with the formic acid amine to obtain the intermediate (V); the final with 2 – chloro – 4 – amino – 6, 7 – dimethoxy quinazoline generate condensation reaction, to obtain the drug kuikui zuo lin kind alfuzosin hydrochloride (VI). Compared with the other production process, the present invention provides a simple operation, safety, easy control of reaction conditions, low energy consumption, yield stable production process, and has good prospects for industrial application. (by machine translation)
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem