The Absolute Best Science Experiment for (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid

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Highly diastereoselective nucleophilic addition reactions of masked acyl cyanide reagents to tert-butanesulfiminides

Addition reactions of dicyanomethyl tert-butyldimethylsilyl ether (H-MAC-TBS) to optically active tert-butanesulfinimides afforded alpha-amino acid precursors in excellent yields and with high diastereoselectivities.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem