A new application about 3-Bromotetrahydrofuran

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3-(4-ETHYNYLPHENYL)HEXAHYDROPYRIMIDIN-2,4-DIONE DERIVATIVES AS MODULATORS OF MGLUR4

The present invention relates to compounds of formula I wherein Y is C-R1; R1′ is hydrogen, F or Cl; R1 is F or Cl; R2 is hydrogen or lower alkyl; R3 is phenyl, pyridinyl or isothiazolyl, wherein the N atom in the pyridinyl group may be in different positions, optionally substituted by one or two halgen atoms; R4 is hydrogen or lower alkyl; Het is a 5-membered heteroaryl group, containg two or three heteroatoms, selected from N, O or S, optionally substituted by lower alkyl, cycloalkyl, lower alkoxyalkyl, heterocycloalkyl, wherein the hetero-atom is O, or lower alkyl substituted by hydroxy, or is a bicyclic heteroaromatic ring, containing two or three N-heteroatoms selected from the groups (II), (III), (IV) or (V) or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds may be used for the treatment of Parkinson’s disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about (S)-4-Hydroxydihydrofuran-2(3H)-one

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Application of 7331-52-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 7331-52-4, molcular formula is C4H6O3, introducing its new discovery.

Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars

A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-gamma-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-gamma-butyrolactone from a 3-leaving group substituted L-pentose sugars. The process uses a base and a peroxide to convert the pentose source to the chiral 3,4-dihydroxybutanoic acid compound. The chiral 3,4-dihydroxybutanoic acid can be further converted to 3-hydroxy-gamma-butyrolactone by acidification. The chiral compound is useful as a chemical intermediate to the synthesis of various drugs and other products.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Final Thoughts on Chemistry for 453-20-3

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Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity

The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea pig, a dose-dependent antithrombotic effect is observed in an established model of arterial thrombosis without prolonging bleeding time. The pharmacodynamic properties of this selective inhibitor are compared to the behaviour of a mixed factor VIIa/factor Xa inhibitor.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome Chemistry Experiments For 3-Hydroxytetrahydrofuran

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Application of 453-20-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2. In a Article£¬once mentioned of 453-20-3

A newly isolated strain capable of effectively degrading tetrahydrofuran and its performance in a continuous flow system

A Gram-negative strain DT4, capable of growing aerobically on tetrahydrofuran (THF) as the sole carbon and energy source was isolated from a pharmaceutical wastewater treatment plant. It was identified as Pseudomonas oleovorans by morphological and physiological characteristics as well as Biolog profiling and 16S rDNA sequence. Cells of P. oleovorans DT4 pre-cultured in THF could degrade 5 mM THF completely without lag phase. The generation time of 2.7 h and the maximum degradation rate of 203.9 mg THF/(h g dry weight) were observed, demonstrating that DT4 bears the highest THF-degrading activity in ever described strains. Furthermore, THF concentration as high as 100 mM was tolerated by the culture. Several important compounds including gamma-butyrrolactone and benzene could be directly metabolized, whereas other pollutants (e.g., tetrahydropyrane) could be cometabolized by DT4. THF removal was achieved in a continuous flow system with the maximum specific growth rate 0.113 h-1 and half-saturation constant 1.224 mg/L, indicating the great potential of THF bioremediation in future full-scale application.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Archives for Chemistry Experiments of Furan-2,4(3H,5H)-dione

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4971-56-6, Name is Furan-2,4(3H,5H)-dione, belongs to Tetrahydrofurans compound, is a common compound. COA of Formula: C4H4O3In an article, once mentioned the new application about 4971-56-6.

The cycloaddition way to novel deoxy disaccharide analogs

A novel heterocycloaddition merges 2-thiono-3-ketolactones with carbohydrate glycals to afford materials which resemble disaccharides with an O-glycosidic linkage at the anomeric center and a thioether linking both C-2 and C-2?, thus creating a third heterocyclic ring. Upon desulfurization, these novel cycloadducts afford materials which are models for 2-deoxydisaccharides. Studies with two keto lactones and seven glycals are described.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Discovery of 4971-56-6

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4971-56-6, name is Furan-2,4(3H,5H)-dione, introducing its new discovery. SDS of cas: 4971-56-6

Treasures old and new: What we can learn regarding the macrocyclic problem from past and present efforts in natural product total synthesis

In this review the strategies leading to successful macrocyclization, in the context of total synthesis are discussed. These synthetic endeavors will be discussed paying particular attention to the methods employed, and including the type of reactive intermediates that could play a key role in key cyclization steps. In many cases “simple” macrocyclization methods were found to be inadequate, and alternative creative approaches were required. For example, we describe Boger’s imaginative development of the intramolecular version of the Larock annulation which yielded the chloropeptin 1 DEF macrocycle. Peptide coupling approaches were unsuccessful. In another example, a key macrocyclic domain within diazonamide was beautifully installed (Nicolaou, et al.) by single electron oxidation/reduction (Witkop reaction), thereby establishing a crucial biaryl functionality. In contrast, oxidative methodologies failed to deliver the distorted biaryl found in haouamine, and Baran, et al. subsequently exploited a spectacular pyrone N-butyne intramolecular Diels-Alder reaction to install this biaryl moiety. Other unexpected and mechanistically intriguing observations will be described throughout the review.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extracurricular laboratory:new discovery of 3-(Bromomethyl)tetrahydrofuran

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SUBSTITUTED INDOLE MCL-1 INHIBITORS

The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic Bcl-2 family proteins, for example, myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides pharmaceutical compositions as well as methods for using provided compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein. In some embodiments, a provided compound has the structure of formula I. In some embodiments, a provided compound has the structure of formula II.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome and Easy Science Experiments about (Tetrahydrofuran-3-yl)methanol

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 15833-61-1, name is (Tetrahydrofuran-3-yl)methanol, introducing its new discovery. name: (Tetrahydrofuran-3-yl)methanol

PHENOXYMETHYL DERIVATIVES

The invention provides novel compounds having the general formula (I), wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about 4971-56-6

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 4971-56-6, and how the biochemistry of the body works.COA of Formula: C4H4O3

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4971-56-6, name is Furan-2,4(3H,5H)-dione, introducing its new discovery. COA of Formula: C4H4O3

Chapter 3: Catalyst-free Organic Reactions with Conventional Heating

This chapter covers catalyst-free synthetic strategies occurring under conventional heating/refluxing conditions for the generation of carbon-carbon and carbon-heteroatom bonds resulting in a wide variety of organic compounds of synthetic and pharmaceutical interests.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The Absolute Best Science Experiment for (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid

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Related Products of 21461-84-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 21461-84-7, molcular formula is C5H6O4, introducing its new discovery.

Highly diastereoselective nucleophilic addition reactions of masked acyl cyanide reagents to tert-butanesulfiminides

Addition reactions of dicyanomethyl tert-butyldimethylsilyl ether (H-MAC-TBS) to optically active tert-butanesulfinimides afforded alpha-amino acid precursors in excellent yields and with high diastereoselectivities.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem