In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 13031-04-4, name is 4,4-Dimethyldihydrofuran-2,3-dione, introducing its new discovery. Recommanded Product: 13031-04-4
A substrate-based folding process incorporating chemodifferentiating ABB’ three-component reactions of terminal alkynoates and 1,2-dicarbonyl compounds: A skeletal-diversity-oriented synthetic manifold
A novel three-component reaction (3CR)-based folding process that is able to generate complexity and skeletal diversity is described. The process utilizes chemodifferentiating organ-ocatalyzed ABB’ 3CRs of a terminal conjugated alkynoate (building block) with alpha-dicarbonyl compounds (diversity-generating blocks) to generate an array of different molecular topologies (gamma-lactones, linear propargylic enol ethers, or 1,3-dioxolane rings). Amides and esters behave as efficient reactivi ty-encoding elements (sigma) of the attached keto functionality. Three chemical properties govern the chemical outcome of this folding process: acidity, nucleophilicity (of the catalyst), and carbonyl electrophilicity. Overall, this substrate-based folding process gener ates three different molecular architectures from the same modular functionalities (ketones) and under the same reaction conditions (methyl propiolate and tertiary amine). In addition, and very importantly for combinatorial applications, all of the products share a common reactive functionality that allows them to be collective substrates for a subsequent diversity-generating process.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 13031-04-4, and how the biochemistry of the body works.Recommanded Product: 13031-04-4
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem