Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of Oxolane-2-carbonyl chloride, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 52449-98-6
Staudinger reactions of unsymmetrical cyclic ketenes: A synthetically useful approach to spiro beta-lactams and derivatives. Reaction mechanism and theoretical studies
An efficient and operationally simple synthesis of tetrahydrofuran-derived spiro-beta-lactams using the ketene-imine cycloaddition route is described. Also the preparation of spiro-N-sulfonyl-beta-lactam derivatives, which are analogs of monobactams, is reported. As far as we know, this is the first time that an unsymmetrical cyclic ketene is used in a Staudinger-type reaction. The experimental evidence suggests the involvement of a ketene derived from the acyl chloride precursor in the reaction. High-level ab initio calculations have been performed in order to get insight into the electronic effects controlling the stereochemical outcome of the reactions.
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem