Awesome and Easy Science Experiments about 87392-05-0

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Optically active tetrahydrofran-2-carboxylic acid manufacturing method (by machine translation)

The issue of the invention is to efficiently manufacture in a high production yield optically active tetrahydrofuran-2-carboxylic acid with optical activity and high purity. The manufacturing method of the optically active tetrahydrofuran-2-carboxylic acid includes three steps: a first step of subjecting (R)- or (S)- tetrahydrofuran-2-carboxylic acid and a salt of an aromatic amine in water to salt exchange by utilization of an inorganic metal alkali, removing the aromatic amine by a hydrocarbon system solvent and/or an ester solvent to obtain a water layer containing the (R)- or (S)- tetrahydrofuran-2-carboxylic acid; a second step of adding an inorganic acid into the water layer obtained in the first step to make the pH to be acid, and extracting with tetrahydrofuran; and a third step of concentrating the extract liquid obtained in the second step and distilling.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem