In heterogeneous catalysis, the catalyst is in a different phase from the reactants. COA of Formula: C5H7ClO2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52449-98-6, name is Oxolane-2-carbonyl chloride. In an article£¬Which mentioned a new discovery about 52449-98-6
Indolinyl-thiazole based inhibitors of scavenger receptor-BI (SR-BI)-mediated lipid transport
A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repository (NIH MLSMR) in an assay measuring the uptake of the fluorescent lipid DiI from HDL particles. This class of compounds is represented by ML278 (17-11), a potent (average IC50 = 6 nM) and reversible inhibitor of lipid uptake via SR-BI. ML278 is a plasma-stable, noncytotoxic probe that exhibits moderate metabolic stability, thus displaying improved properties for in vitro and in vivo studies. Strikingly, ML278 and previously described inhibitors of lipid transport share the property of increasing the binding of HDL to SR-BI, rather than blocking it, suggesting there may be similarities in their mechanisms of action.
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem