4971-56-6, Name is Furan-2,4(3H,5H)-dione, belongs to Tetrahydrofurans compound, is a common compound. COA of Formula: C4H4O3In an article, once mentioned the new application about 4971-56-6.
Pesticide residues in chicken eggs – a sample preparationmethodology for analysis by gas and liquid chromatography/tandemmass spectrometry
A sample preparation method was developed for the analysis of chicken eggs to determine 97 GC and81 LC amenable residues, including organophosphates, organochlorines, pyrethroids, triazoles, carboxyl-containing compounds, and the indicator PCBs. Hereby, considerations were given to the recoveries ofthe analytes, the method’s suitability for routine analysis, and the assessment of the clean-up effect,for which a simple thin layer chromatography was implemented to visualize the most important lipidclasses.The procedure consisted of (I) the extraction by matrix solid phase dispersion, and the clean-up bymeans of (II) small-scale gel permeation chromatography (GPC) and (III) two different solid phase extrac-tions (SPE) for GC and LC amenable analytes, as well as (IV) the quantification using GC-MS/MS andLC-MS/MS. Cyclohexane/ethyl acetate was chosen as extraction solvent due to its suitability for extract-ing strong non-polar but also more polar analytes. The classical GPC was scaled down to ensure a 50%lower solvent consumption. The comprehensive investigation of conventional and modern zirconium-oxide-coated SPE materials resulted in the selection of octadecyl-modified silica (C18) combined withprimary secondary amine using acetonitrile as elution solvent for GC amenable analytes and pure C18 incombination with acidified methanol for LC amenable pesticides.Compared to the currently established EN 1528 method the sample preparation proposed offered ahigher sample throughput and a lower solvent consumption. Furthermore, for the first time the clean-up effectiveness of the sample preparation steps was documented as shown by means of thin-layerchromatography.The validation of chicken eggs proved the fulfillment of the quality control criteria for 164 of the 178 analytes tested, mostly at the lowest validated level of 5mug/kg for pesticides and 0.5mug/kg for the singleindicator PCBs. However, the analysis of strongly polar analytes was still problematic, which could beattributed to the extraction and the GPC step. Nevertheless, the successful investigation of EU proficiencytest materials (EUPT AO 07-09) confirmed the comparability of the results with the currently establishedsample preparation procedures and demonstrated the potential of the applicability of the presentedmethod to other matrices as exemplified for lean poultry meat and fatty liquid cream.
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem