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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52079-23-9, name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone. In an article£¬Which mentioned a new discovery about 52079-23-9
Synthesis of 1alpha,25-dihydroxy-24R-fluorocholecalciferol and 1alpha,25-dihydroxy-24S-fluorocholecalciferol
1alpha,25-Dihydroxy-24R-fluorocholecalciferol and 1alpha,25-dihydroxy-24S-fluorocholecalciferol, analogs of 1alpha,25-dihydroxy-cholecalciferol which is physiologically the most active metabolite of vitamin D3, are synthesized in a multistep process from the known substance 1alpha,3beta-dihydroxyandrost-5-en-17-one. The new analogs are characterized by the ability to increase intestinal calcium transport, increase serum calcium and phosphate concentrations and to increase the deposition of these minerals in bones. These compounds will find a ready application as substitutes for natural 1alpha,25-dihydroxycholecalciferol in the treatment of disease states characterized by metabolic calcium and phosphate deficiencies. Exemplary of such disease states are the following: osteosclerosis, anticonvulsant treatment, osteopenia, fibrogenesis-imperfecta ossium, secondary hyperparathyrodism, hypoparathyroidism, hyperparathyroidism, cirrhosis, obstructive jaundice, drug induced metabolism, medullary carcinoma, chronic renal disease, hypophosphatemic VDRR, vitamin D-dependent rickets, sarcoidosis, glucocorticoid antagonism, malabsorption syndrome, steatorrhea, tropical sprue, idiopathic hypercalcemia and milk fever.
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem