Reference of 5455-94-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 5455-94-7, 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, introducing its new discovery.
Regiocontrolled Formation of 4,5-Dihydro-3(2H)-furanones from 2-Butyne-1,4-diol Derivatives. Synthesis of Bullatenone and Geiparvarin
Two new methods for selective hydration of 1,1,4-trisubstituted 2-butyne-1,4-diols (1) to give 4,5-dihydro-3(2H)-furanone derivatives are reported.The first involves selective monoacetylation of the less hindered hydroxyl group of 1 followed by Ag(I)-catalyzed rearrangement and cyclization to give 3-acetoxy-2,2,5-trisubstituted 2,5-dihydrofurans (2).Final hydrolysis yielded 2,2,5-trisubstituted 4,5-dihydro-3(2H)-furanones.Oxidation of the enol acetates 2 with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone gave 3(2H)-furanones.The new method was applied to the synthesis of naturally occurring 3(2H)-furanones such as bullatenone and geiparvarin from the corresponding 2-butyne-1,4-diol derivatives.The second approach is concerned with the synthesis of the opposite regioisomer, 2,5,5-trisubstituted 4,5-dihydro-3(2H)-furanones, from diols 1 with a polymer reagent Hg/Nafion-H.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 5455-94-7. In my other articles, you can also check out more blogs about 5455-94-7
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem