19311-37-6, 3-Bromotetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Methyl 6hydroxypyrazoio[1,5-aipyridine-3-carboxy1ate (0.200 g, 1.04 mrnol) was suspended in MeCN (10 rnL), then 3-bromotetrah drofuran (0.131 mL, 1.35 mniol), K2COS (0575 g, 416 mmol) and 1-120 (0.667 rnL) were added. The reaction mixture was stirred under microwave irradiation at 120 C for 30 mm, The reaction mixture wasconcentrated under reduced pressure, the residue dissolved in MeOH (4 rnL)/THF (4 mL), and IM LiOH (4.16 mL, 4.16 mniol) was added. The reaction mixture was stirred under microwave irradiation at 150 C for 15 mm. The reaction mixture was acidified with TFA. filtered, and purified by reverse phase HPLC to afford 6-((tetrahydrofuran-3- y1)oxv)pyrazoIoI.5ajpyridine-3-carboxviic acid (0.155g. 60 %yieid) as an off-whitesolid. MS (ESI) m/-: 249.0 (M-FH)t ?FT NMR (500MHz. DMSO-d6) oe ppm 12.36 (hr s.1H), 8.58 (d. J=i.7 Hz, 1H), 8.30 (s, 1H), 7.96 (d. J=9.6 Hz, IH), 7.34 (dd, J=9.6, 2.2 Hz, IH), 5.12 (ddt, J=6.1, 4.0, 1.7 Hz, IH), 3.93-3.83 (rn. 3H), 377 (td, J=S4, 4.4Hz, 1H), 232 2.20 (n, 1H), 2.09 – 1.98 (m, 11-1).
19311-37-6, The synthetic route of 19311-37-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; SMITH II, Leon M.; LADZIATA, Vladimir; DELUCCA, Indawati; PINTO, Donald, J., P.; ORWAT, Michael J.; DILGER, Andrew K.; PABBISETTY, Kumar Balashanmuga; YANG, Wu; SHAW, Scott A.; GLUNZ, Peter W.; PANDA, Manoranjan; (612 pag.)WO2017/123860; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem