97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
97-99-4, In a round bottom flask was placed (R)-(tetrahydro-furan-2-yl)-methanol (prepared as in PCT WO 2003/095438 A1, Example 3, 4.65 g, 45.5 mmol), methylene chloride (100 mL) and triethylamine (8.4 mL, 60.6 mmol) and it was cooled to 0 C. To this cooled solution was then added a solution of p-toluenesulfonyl chloride (10.4 g, 54.6 mmol) in methylene chloride (30 mL) dropwise. Once the addition was complete the reaction was then warmed to 25 C. and stirred for 16 h. The reaction was then diluted with water (50 mL) and extracted with methylene chloride (3¡Á30 mL). The combined organic extracts were then dried over sodium sulfate, filtered and concentrated in vacuo. Purification on an AnaLogix Intelliflash system (80 g column, 3% ethyl acetate/hexanes to 40% ethyl acetate/hexanes) afforded toluene-4-sulfonic acid tetrahydro-furan-2(R)-ylmethyl ester (8.37 g, 72%) as a clear colorless oil: [alpha]32589=-14.4 (c=0.72, methylene chloride); ES-HRMS m/e calcd for C12H16O4S (M+H)+ 257.0842, observed 257.0841; 1H NMR(300 MHz, CDCl3) delta ppm 1.95-2.08 (m, 1 H, CH of CH2), 2.14-2.40 (m, 3 H, CH2 and CH of CH2), 4.02-4.19 (m, 2 H, OCH2), 4.29-4.49 (m, 3 H, OCH and OCH2), 7.69 (d, J=8.0 Hz, 2 H, Ar), 8.15 (d, J=8.0 Hz, 2 H, Ar).
As the paragraph descriping shows that 97-99-4 is playing an increasingly important role.
Reference£º
Patent; Berthel, Steven Joseph; Kester, Robert Francis; Murphy, Douglas Eric; Prins, Thomas Jay; Ruebsam, Frank; Sarabu, Ramakanth; Tran, Chinh Viet; Vourloumis, Dionisios; US2008/21032; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem