With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
Production Example 243 (0564) 5-[3-(4-Chlorophenyl)propyl]isoxazole-3-carboxylic acid (0.78 g, 2.9 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.60 g, 4.4 mmol), triethylamine (0.44 g, 4.4 mmol) and 1-hydroxybenzotriazole (0.04 g, 0.3 mmol) were added to a mixed solvent of chloroform (amylene addition product) (4 mL) and tetrahydrofuran (4 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.67 g, 3.5 mmol) was added to the mixture at room temperature, and the mixture was stirred at room temperature overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and saturated saline water and dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.78 g of N-(tetrahydrofuran-3-ylmethyl)-5-[3-(4-chlorophenyl]propyl) isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (252)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta (ppm)) : 1.62-1.73 (1H, m), 1.99-2.15 (3H, m), 2.53-2.63 (1H, m), 2.66(2H, t), 2.80(2H, t), 3.46(2H, t), 3.59 (1H, dd), 3.73-3.80 (1H, m), 3.83-3.95(2H, m), 6.46 (1H, s), 6.92 (1H, br s), 7.11(2H, d), 7.27(2H, d)
184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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