138498-97-2, 2-(Tetrahydrofuran-3-yl)acetic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 58N-(2,5-dichloro-3-(((S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)phenyl)-2- (tetrahydrofuran-3-yl)acetamide (E58)H(YNNYpTo a suspension of 2-(tetrahydrofuran-3-yl)acetic acid (39.4 mg) in DCM (10 mL), oxalyl chloride (0.030 mL) was added dropwise. The reaction mixture was stirred at 40C for 30 mm. Solvent wasremoved by rotavap, then re-dissolved with DCM (1 mE), added to a solution of (S)-(4-(3 -amino2,5-dichlorobenzyl)-2-methylpiperazin-1 -yl)(cyclopentyl)methanone (D158, 70 mg) in pyridine (2 mL). The reaction mixture was stirred at RT overnight. The reaction mixture was diluted with DCM (10 mL) then washed with brine (10 mE). DCM layer was separated and concentrated. The residue was purified by MADP to afford the title compound (7 mg) as white solid. 111 NMR (400 MHz, MeOD-d4): 7.71 (d, J= 1.5 Hz, 1H), 7.35 (d, J= 2.0 Hz, 1H), 4.61 (brs, 0.5H), 4.33-4.17 (m, 1H), 3.90-3.51 (m, 5.5H), 3.45-3.27 (m, 1.5H), 3.01-2.67 (m, 3.5H), 2.67-2.41 (m, 3.5H), 2.27 (brs, 1H), 2.14-1.99 (m, 1.5H), 1.84-1.43 (m, 1011), 1.35-1.13 (m, 3H). MS (ESI): C24H33C12N303requires 481; found 482 {M+H].
138498-97-2, As the paragraph descriping shows that 138498-97-2 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem