With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.
Lithium l-benzyl-2-(l,5-dimethyl-6-oxo-l,6-dihydropyridin-3-yl)-lH-imidazole-4- carboxylate (for an example preparation, see Intermediate 13, 10 mg, 0.030 mmol) was added to a vial containing a stirrer bar, and dissolved in DMF (0.25 mL). HATU (12.70 mg, 0.033 mmol) was added, and the reaction mixture stirred under an atmosphere of nitrogen at RT for lh. A solution of rac-tetrahydrofuran-3-amine (5.29 mg, 0.061 mmol) and DIPEA (10.61 muIota, 0.061 mmol) in DMF (0.25 mL) was added, and the reaction stirred for a further lh. The sample was diluted to 0.9 mL with methanol and purified by MDAP (Method B). The solvent was evaporated in vacuo to give the title compound as a colourless oil (8.0 mg, 0.02 mmol, 67percent). LCMS (System B): tRET = 0.75 min; MH+ 393., 88675-24-5
The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; BAXTER, Andrew; BIT, Rino, Antonio; BROWN, John, Alexander; HIRST, David; HUMPHREYS, Philip; JONES, Katherine, Louise; PATEL, Vipulkumar, Kantibhai; (124 pag.)WO2018/41964; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem