4100-80-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4100-80-5,3-Methyldihydrofuran-2,5-dione,as a common compound, the synthetic route is as follows.
EXAMPLE II Preparation of 4-(5,8-methano-5,6,7,8-tetrahydro-2-naphthyl)-4-oxo-2-methyl butyric acid Compound of formula I where A=–CH2 –2, R1,R3 =–CH2 –, R2 =R4 =H, R5 =R6 =H, R’,R”=oxo, R7 =OH and R8 =CH3 To a suspension of 13.33 g (0.1 mole) of anhydrous aluminum chloride in 70 cm3 of dry dichloromethane, stirred at ambient temperature, there is slowly added, over about a 30 minute period, an equimolar solution of 7.11 g (0.05 mole) of 1,4-methano-1,2,3,4-tetrahydronaphthalene and 5.7 g (0.05 mole) of methylsuccinic anhydride in 50 cm3 of dry dichloromethane. At the end of the addition, the reaction mixture is stirred for 1 additional hour at ambient temperature, and it is then poured into 100 cm3 of ice water. The organic phase is decanted and the aqueous phase is again extracted twice with 100 cm3 of dichloromethane. The dichloromethane phases are washed with water, dried on sodium sulfate and then evaporated to dryness. The resulting crude oil is crystallized by trituration in 100 cm3 of tepid hexane. After filtration, the resulting beige solid is recrystallized in 120 cm3 of a 90/10 hexane/acetone mixture, thereby yielding 5.1 g of white crystals which are taken up in 50 cm3 of isopropyl ether, filtered and again recrystallized in 80 cm3 of a 60/40 isopropyl ether/hexane mixture. After drying, 1.7 g of 4-(5,8-methano-5,6,7,8-tetrahydro-2-naphthyl)-4-oxo-2methyl butyric acid in the form of a white solid whose melting point is 148¡ã C. are obtained. The NMR1 H 250 MHz and 13 C spectra conform to the expected structure.
The synthetic route of 4100-80-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Societe Anonyme Dite: L’Oreal; US5068393; (1991); A;,
Tetrahydrofuran – Wikipedia
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