97-99-4,97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: NaH (38.5 mg, 0.96 mmol (60% in mineral oil)) was added to a 50 ml round-bottom flask and dry DMF was added.(DMF will not dissolve NaH but it will be a suspension). To this mixture was added 2-fluoroethanol (18.50 mg, 0.29 mmol) at room temperature, and the mixture wasstirred for 10 min.To the suspension was added 2-(3-(5-fluoropyridin-3-yl)phenyl)imidazo[1,2-a]pyridine-8-carboxamide (80 mg, 0.24 mmol), and the resulting mixture was heated at 100C for 2 hr.The DMF was evaporated, and the crude material was purified by silica gel column chromatography eluting with 0-20% MeOH/DCM. The material thus produced was further purified by Gilson Prep HPLC to obtain desired product 2-(3-(5-(2-fluoroethoxy)pyridin-3-yl)phenyl)imidazo[1,2-a]pyridine-8-carboxamide (15.00 mg, 16.56 %).
The synthetic route of 97-99-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ramachandran, Sreekanth; Panda, Manoranjan; Mukherjee, Kakoli; Choudhury, Nilanjana Roy; Tantry, Subramanyam J.; Kedari, Chaitanya Kumar; Ramachandran, Vasanthi; Sharma, Sreevalli; Ramya; Guptha, Supreeth; Sambandamurthy, Vasan K.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4996 – 5001;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem