16874-34-3, Ethyl tetrahydrofuran-2-carboxylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 229 – Preparation of Intermediate 56 The synthesis of Intermediate 56 followed the procedure of General Procedure 2 following: Intermediate 55 Intermediate 56 To a cooled (0C) solution of ethyl tetrahydrofuran-2-carboxylate (Intermediate 55, 6 g, 41.66 mmol in THF (100 mL), dry acetonitrile (3.4 mL, 83.33 mmol) was added. After 10 min, LHDMS (1M in THF, 13.9 g, 83.3 mmol) was added. After stirring at 0C for 2 hours, the mixture was quenched with saturated citric acid solution until pH=5 and extracted into Ethyl acetate (3 x 200 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated under reduced pressure to give 3-oxo-3-(tetrahydrofuran-2-yl)propanenitrile (Intermediate 56, 7.5 g, yield: 99%) as an oily residue that was used without further purification into the next step. m/z 140.02 [M+H]+; TLC System: 10% Methanol- dichloromethane; Rf-0.4., 16874-34-3
As the paragraph descriping shows that 16874-34-3 is playing an increasingly important role.
Reference£º
Patent; VERSEON CORPORATION; SHORT, Kevin Michael; ESTIARTE-MARTINEZ, Maria de los Angeles; KITA, David Ben; SHIAU, Timothy Philip; (340 pag.)WO2016/138532; (2016); A1;,
Tetrahydrofuran – Wikipedia
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