With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
The raw material 12 – carbonyl oleanolic acid (189 mg, 0 . 40 mmol) is dissolved in anhydrous pyridine (3 ml) in, adding 2, 2 – dimethyl succinic anhydride (256 mg, 2 mmol), DMAP (49 mg, 0 . 40 mmol), after dissolving completely, microwave reactor is heated to 160 ¡ãC, reaction 3 h. The end of the reaction, by adding ethyl acetate (50 ml), for 10percent HCl to adjust the pH 4 – 5; organic layer is saturated salt water washing (25 ml ¡Á 3), dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure to remove the solvent, silica gel column chromatography (hexane: ethyl acetate=1:1), to obtain white solid 202 mg, is compound 17, yield 68percent.
17347-61-4, The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chen Zhong; Duan Huaqing; Yang Shilin; Li Guoxiong; (26 pag.)CN109485688; (2019); A;,
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