With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
Under nitrogen atmosphere, to a mixture of 1.4 g of (tetrahydrofuran-3-yl)methylamine hydrochloride (Reference Production Example 3) and 20 ml of anhydrous tetrahydrofuran, 1.0 g of triethylamine was added at room temperature and: stirred for 30 minutes. To the mixed liquid, 0.63 g of (2E, 4E) -hepta-2 , 4-dienoic acid and 1.9 g of l-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride were added, and stirred for 4 hours at room temperature. Then, to the reaction mixture, water was added and extracted with ethyl acetate 2 times. The organic layer was washed with brine, and dried over anhydrous sodium sulfate, then, concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 0.75 g of (2E, 4E) -N- (tetrahydrofuran-3-ylmethyl) hepta-2, 4-dienamide of the formula :(hereinafter, referred to as The Present Compound (5)).( 5 )[0105]The Present Compound (5)1H NMR (GDC13) : delta ppm: 7.24-7.16 (1H, m) , 6.15-6.10 (2H, m) , 5.74 (1H, d) , 5.61 (1H, brs), 3.89 (1H, td) , 3.81 (1H, dd) , 3.74 (1H, q) , 3.55 (1H, dd) , 3.42-3.31 (2H, m) , 2.57-2.47 (1H, m) , 2.22-2.14 (2H, m) , 2.09-1.99 (1H, m) , 1.67-1.57 (1H, m) , 1.03 (3H, t)
184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MATSUO, Noritada; OHSHITA, Jun; WO2012/133861; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem