17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3,3-DIMETHYL-DIHYDRO-FURAN-2,5-dione (6.4g) was heated at [50OC] in ethanol (150 [ML)] overnight. The solvent was removed in vacuo and the residue triturated with hexane to yield 2, [2-DIMETHYL-SUCCINIC] acid 4-ethyl ester (4.66g) which was used without further purification. t-Butanol (7.5 mL) was added to a mixture of 2,2-Dimethyl-succinic acid 4- ethyl ester (2.74g, 15. [7MMOL)] in dichloromethane (62 mL) containing magnesium sulfate (7.5 g) and [CONC.] sulfuric acid (0.85 mL) and the mixture was stirred at room temperature overnight. Saturated sodium bicarbonate solution was added and the product was extracted into dichloromethane, washed with brine solution, dried and concentrated to yield the diested as a colorloess oil (1.89 g). The ethyl ester was hydrolyzed by trating the crude sample with potassium hydroxide (2.75g) in a mixture of ethanol (50 [ML)] and water (25 mL) at room temperatire for 2h. The reaction was acidified using 1N [HC1] [(AQ)] and extracted into ether, dried and concentrated to yield 2,2-Dimethyl-succinic acid [1-TERT-BUTYL] ester (1.4g). This acid was treated under the conditions of Example 320 (step 1) to yield 3- [[3- (3-CHLORO-PHENYL)- [1,] 2,4] oxadiazol-5-yl] -2,2-dimethyl-propionic acid tert-butyl ester (1.9g). This t-Bu ester was deprotected using formic acid (19 mL) at [50¡ãC] for 20 min. The crude product was concentrated and triturated with a mixture of ether and hexane to yield [3- [3- (3-CHLORO-PHENYL)- [1,2,4] [OXADIAZOL-5-YL]-2,] 2-dimethyl-propionic acid (1.12g). To a solution [OF 3- [3- (3-CHLORO-PHENYL)- [1,2,4] oxadiazol-5-yl] -2,2-dimethyl-propionic acid (561 mg, 2 mmol) and triethylamine [(1.] [1] [ML,] 8 mmol) in THF (9 ml), isobutyl chloroformate (0.31 mL, 2.4 mmol) was added dropwise [AT-78 ¡ãC.] After being stirred for lh, hydrazine hydrate (1 mL, 11 mmol) was added. The reaction mixture was stirred at room temperature for 1 h and concentrated. A small amount of ice was added to quence any excess reagent and precipitate the product, which was collected by filtration to give 482 mg of the title compound., 17347-61-4
17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
Tetrahydrofuran – Wikipedia
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