184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Production Example 153 (0473) Tetrahydrofuran-3-ylmethylamine hydrochloride (150 mg, 1.09 mmol) and a 1 mol/L aqueous sodium hydroxide solution (8 mL) were simultaneously added to a toluene solution (10 mL) of 5-(benzo[b]thiophen-2-ylmethy)isoxazole-3-carboxylic acid chloride (< 0.38 mmol), under ice-water cooling. The mixture was vigorously stirred for 30 minutes under ice-water cooling, and then the reaction mixture was extracted once with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 104 mg of N-(tetrahydrofuran-3-ylmethyl)-5-(benzo[b]thiophen-2-ylmeth y)isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (161)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta(ppm)):1.62-1.71(m, 1H), 2.03-2.13(m, 1H), 2.50-2.63(m, 1H), 3.43-3.48 (m, 2H), 3. 58 (dd, J=8. 9, 5. 3Hz, 1H), 3.72-3.79(m, 1H), 3.82-3.94(m, 2H), 4.41(s, 2H), 6.58(s, 1H), 6.91 (s, 1H), 7.16(s, 1H), 7.29-7.37(m, 2H), 7.69-7.73(m, 1H), 7.76-7.81(m, 1H) 184950-35-4, As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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