87392-05-0,87392-05-0, (R)-(+)-2-Tetrahydrofuroic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (2R)-tetrahydrofuran-2-carboxylic acid (2 g, 17.22 mmol) in THF (20 mL) was added the BH3. SMe2 (2.58 mL, 25.84 mmol) at 0C, then the mixture was stirred at 20 C for 16 hours to give the colorless solution.. 2N NaOH (10 mL) was added to the mixture slowly at 0 C. Then the mixture was extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2SC>4, filtered and concentrated to give the crude product (450.00 mg, 4.41 mmol, 26% yield) as colorless oil. *H NMR (CDC13, 400MHz) deltaH = 4.07 – 3.97 (m, 1H), 3.94 – 3.85 (m, 1H), 3.84 – 3.76 (m, 1H), 3.72-3.63 (m, 1H), 3.55 – 3.46 (m, 1H), 2.02 – 1.87 (m, 4H), 1.72 – 1.65 (m, 1H).
The synthetic route of 87392-05-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
Tetrahydrofuran – Wikipedia
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