Day: November 17, 2020

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- (2,3-difluorobenzyloxymethyl) isoxazole-3-carboxylic acid (0.54 g, 2.0 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (0.41 g, 3.0 mmol), Triethylamine (0.30 g, 3.0 mmol) And 1 – hydroxybenzotriazole (0.03 g, 0.2 mmol) Was added to chloroform (amylen added product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.46 g, 2.4 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, Washed with saturated brine, After drying with anhydrous sodium sulfate, Reduction It was concentrated under pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (2,3-difluorobenzyloxymethyl) isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (274)) 0.25 g was obtained.

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22929-52-8,Dihydrofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: Similar to as described in General Procedure Y Step 1, diethyl oxalate was reacted withoxolan-3-one to give 400 mg (5percent) of ethyl 2-oxo-2-(4-oxooxolan-3-yl)acetate as yellow oil..; Step 1: A solution of cycloalkylketone (1.0 eq.) in EtOH (0.5 mL/mmol) was cooled to 0 ¡ãC, then sodium ethoxide (21percent wt solution in EtOH, 1.1 eq.) was added. To this mixture was added diethyl oxylate (1.0 eq.) and the mixture was allowed to warm to room temperature overnight. In vacuo concentration provided the desired product of sufficient purity to be used directly (yield assumed to be quantitative)., 22929-52-8

The synthetic route of 22929-52-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25025; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.

In a 25L reaction flask,678 g (7.7 mol) of 3-hydroxy tetrahydrofuran was dissolved in 8 L of anhydrous dichloromethane,then add 1.13 L (14mo 1) anhydrous pyridine. The reaction solution was cooled to 0 C and a solution of acetyl chloride (600 ml, 8.4 mol 1) in dichloromethane (2 L) was slowly added along with stirring. After dripping up to 25 C for about two hours, continue to stir for 3 hours, After completion of the reaction, (10 L)water was added to the reaction solution, and the mixture was allowed to stand for half an hour. After complete delamination, the dichloromethane layer was collected , evaporated and dried under reduced pressure to give 910 g of tetrahydrofuranyl-3-acetate (racemic) , 91% yield as a colorless liquid.

453-20-3, 453-20-3 3-Hydroxytetrahydrofuran 9960, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Hangzhou Shukang Biological Co., Ltd.; Lin Lu; (10 pag.)CN106957287; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

1-benzyl-1 H-1,2,3-triazole-4-carboxylic acid (0.96 g, 4.7 mmol) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.71 g, 5.2 mmol), Triethylamine (1.01 g, 10 mmol) And 1-hydroxybenzotriazole (0.08 g, 0.52 mmol) Was added to chloroform (amylene addition product) (30 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (1.00 g, 4.2 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate and it was extracted twice with ethyl acetate. The organic layer was washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, 1-benzyl-1H-1,2,3-triazole-4-carboxamide represented by the following formula (hereinafter referred to as present amide compound (9)) 0.86 g was obtained., 184950-35-4

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.

88675-24-5, Example 31: l-(5,6-dichloro-l-isopropyl-lH-benzo[d]imidazol-2-yl)-iV-(tetrahydrofuran-3- yl)piperidine-4-carboxamide(a) Preparation of the intermediary compound l-(5,6-dichloro-lH-benzo[d]imidazol-2-yl)-N- (tetrahydrofuran-3-yl)piperidine-4-carboxamide To a solution of l-(5,6-dichloro-lH-benzoimidazol-2-yl)-piperidine-4-carboxylic acid (0.3 g, 0.95 mmol) in N,Lambda/-dimethylformamide (5 niL) was added 2-(7-aza-lH-benzotriazole-l-yl)- 1,1,3,3-tetramethyluronium hexafluorophosphate (EtaATU, 0.544 g, 1.4 mmol) followed by N,N- diisopropylethylamine (Etaunig’s base, DIEA, 0.33 mL, 1.9 mmol) and tetrahydrofuran-3 -amine (0.1 g, 1.1 mmol). The reaction mixture was stirred at room temperature for 5 hours,concentrated in vacuo and extracted with ethyl acetate (2 x50 mL). The combined organic phases were dried over anhydrous sodium sulphate and subjected to column chromatography(chloroform/methanol 95:5) to give 0.135 g (37 percent yield) of l-(5,6-dichloro-lH- benzo[d]imidazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide. LC-MS (m/z) 383.2 (M+l).

As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; NOVASAID AB; WANNBERG, Johan; ALTERMAN, Mathias; MALM, Johan; STENBERG, Patric; WESTMAN, Jacob; WALLBERG, Hans; WO2011/23812; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Production Example 244 (0565) Tetrahydrofuran-3-ylmethylamine hydrochloride (1.00 g, 7.26 mmol) and a 1 mol/L aqueous sodium hydroxide solution (16 mL) were simultaneously added at room temperature to the ethyl acetate solution (30 mL) of 5-[(2-naphthylmethy)thiomethyl]isoxazole-3-carboxylic acid chloride (< 3.67 mmol) obtained in Reference Production Example 197. After vigorously stirring the mixture at room temperature for 1 hour, a 1 mol/L aqueous sodium hydroxide solution was added to the mixture. The fractionated organic layer was sequentially washed with water and saturated saline water, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure.. The residue was applied to a silica gel column chromatography to obtain 480 mg of N-(tetrahydrofuran-3-ylmethyl)-5-[(2-naphthylmethyl)thiomet hyl]isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (253)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta (ppm)) : 1.63-1.75 (1H, m), 2.04-2.15 (1H, m), 2.52-2.62 (1H, m), 3.42-3.50(2H, m), 3.57-3.67(3H, m), 3.73-3.98 (5H, m), 6.59(1H, s), 6.89(1H, br s), 7.45-7.56(3H, m), 7.69 (1H, s), 7.79-7.88(3H, m), 184950-35-4

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

165253-29-2, 3-(Bromomethyl)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 DMPU (225ml), FeCl3(0.75g) and CuCl (0.3g) are added to 3-bromomethyltetrahydrofuran (24.75g, 0.138mol), and then Et2Zn (106.8ml) is slowly dropped at 40~45 ¡ãC for 45 minutes to obtain a zinc-reagent. THF (810 ml) and PdCl2(dppf) (5.09g) are added to 4-chloro-2-(4-chlorophenyl)-thieno[2,3-d] pyridazinyl-7-ethyl formate (30g), and then the zinc-reagent is dropped to the THF solution at 45¡ãC for 4 h. The reaction mixture is poured into a saturated brine, filtrated after stirring for 15 minutes and placed for layer separation.The aqueous phase is extracted with THF (500 ml, 2 times). The organic phase is combined together, washed with a saturated brine (500ml, 3 times) and dried with anhydrous Na2SO4, and evaporated under reduced pressure to remove solvent to obtain 4-(3-tetrahydropyranmethyl)-2-(4-chlorophenyl)-thieno [2,3-d] pyridazinyl -7-ethyl formate (25 g). MS (ESI): 403(M+1), 165253-29-2

As the paragraph descriping shows that 165253-29-2 is playing an increasingly important role.

Reference£º
Patent; Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory; EP2241569; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

87392-05-0,87392-05-0, (R)-(+)-2-Tetrahydrofuroic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (2R)-tetrahydrofuran-2-carboxylic acid (2 g, 17.22 mmol) in THF (20 mL) was added the BH3. SMe2 (2.58 mL, 25.84 mmol) at 0C, then the mixture was stirred at 20 C for 16 hours to give the colorless solution.. 2N NaOH (10 mL) was added to the mixture slowly at 0 C. Then the mixture was extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2SC>4, filtered and concentrated to give the crude product (450.00 mg, 4.41 mmol, 26% yield) as colorless oil. *H NMR (CDC13, 400MHz) deltaH = 4.07 – 3.97 (m, 1H), 3.94 – 3.85 (m, 1H), 3.84 – 3.76 (m, 1H), 3.72-3.63 (m, 1H), 3.55 – 3.46 (m, 1H), 2.02 – 1.87 (m, 4H), 1.72 – 1.65 (m, 1H).

The synthetic route of 87392-05-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Production Example 255 (0576) 5-(2-Fluorobenzyloxymethyl)isoxazole-3-carboxylic acid (0.75 g, 3.0 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.62 g, 4.5 mmol), triethylamine (0.46 g, 4.5 mmol) and 1-hydroxybenzotriazole (0.04 g, 0.3 mmol) were added to chloroform (amylene addition product) (7.5 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.69 g, 3. 6 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and saturated saline water and dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.44 g of N-(tetrahydrofuran-3-ylmethyl)-5-(2-fluorobenzyloxymethyl)i soxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (264)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta (ppm)) : 1.62-1.73 (1H, m), 2.05-2.14 (1H, m), 2.52-2.63 (1H, m), 3.47 (2H, t), 3.59 (1H, dd), 3.73-3.80 (1H, m), 3.83-3.95(2H, m), 4.68(2H, s), 4.69(2H, s), 6.74 (1H, s), 6.95 (1H, br s), 7.03-7.10 (1H, m), 7.13-7.19 (1H, m), 7.28-7.35 (1H, m), 7.38-7.45 (1H, m)

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.,453-20-3

[00303] To a solution of Example 20k (500 mg, 4.90 mmol) in DCM (15mL) wereadded Et3N (980 mg, 9.80 mmol) and MsCl (670 mg, 5.88 mmol) at 0C. The mixture was stirred at 0C for 2 h. Water (50 mL) was added into the mixture, which was extracted with DCM (15mL*3). The combined organic layerwas concentrated under reduced pressure to afford the crude product Example 201 (950 mg, crude yield 100%) as yellow oil, which was used in the next step without further purification.

The synthetic route of 453-20-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (214 pag.)WO2019/51265; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem