52079-23-9, (S)-(-)-alpha-Hydroxy-gamma-butyrolactone is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52079-23-9
To a suspension of NaH (60% in mineral oil, 552 mg, 12.0 mmol) in THF (5 mL) was added a solution of (S)-3-hydroxydihydrofuran-2(3H)-one (46a, 1.02 g, 10.0 mmol) in TetaF (5 mL) slowly drop wise at 0 0C under N2 atmosphere. The reaction mixture was stirred for 30 minutes and dimethylsulphate (1.4 mL, 15.0 mmol) was added. The reaction mixture was stirred at r.t. overnight and the TLC shows completion of the reaction. Cold water (25 mL) was added to the reaction mixture and extracted with ethyl acetate. Organic layer washed with brine, dried over anhydrous Na2SO4 and filtered. Concentrated to provide (S)-3-hydroxydihydrofuran-2(3H)- one (46a) as yellow oil, which was dissolved in MeOH. Catalytic amount of K2CO3 (50 mg) was added at 0 0C and the reaction mixture stirred for Ih. TLC shows completion of the reaction. Cold water (25 mL) was added to the reaction mixture and extracted with ethyl acetate. Organic layer washed with brine, dried over anhydrous Na2SO4 and filtered. Concentrated to provide (S)- methyl 4-hydroxy-2-methoxybutanoate (46b, 1.5g, 99%) as yellow oil. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 2.07 – 2.28 (m, 1 H) 2.36 – 2.58 (m, 1 H) 3.36 (s, 3 H) 3.49 (s, 3 H) 3.85 – 4.07 (m, 1 H) 4.29 – 4.42 (m, 2 H).
52079-23-9 (S)-(-)-alpha-Hydroxy-gamma-butyrolactone 357853, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/97578; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem