With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19311-37-6,3-Bromotetrahydrofuran,as a common compound, the synthetic route is as follows.
Example 57: 5-methyl-2-{3-i4-(methylsulfonyl)phenoxy1-5-(tetrahvdrofuran- 3-yloxy)phenyl}pyrimidin-4(3H)-oneA mixture of 5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)benzene-1 ,3- diol (125 mg, 0.369 mmol), 3-bromotetrahydrofuran (55 mg, 0.369 mmol) and potassium carbonate (102 mg, 0.738 mmol) in N,N-dimethylformamide (1 ml_) was stirred at 80C overnight. The reaction mixture was cooled to room temperature. 4-Fluorophenylmethylsulfone (65 mg, 0.369 mmol) and additional potassium carbonate (102 mg, 0.738 mmol) were then added to the reaction. The reaction mixture was stirred at 80C for 2 days. The cooled reaction mixture was treated with trifluoroacetic acid (0.75 ml_) for 3 hours, then diluted with EtOAc and washed with saturated aqueous sodium bicarbonate solution, dried over sodium sulfate and purified by HPLC to afford the title compound (11.3 mg, 19%). MS (M+1): 443.1. Column:Waters Atlantis C184.6mm x 50 mm, 5 muetaeta; Modifier: TFA 0.05%; Gradient: 95% H20 / 5% MeCN linear to 5% H20 / 95% MeCN over 4.0 minutes HOLD at 5% H20 / 95% MeCN to 5.0 minutes. Flow: 2.0 mL / min.; RT: 2.43 min., 19311-37-6
As the paragraph descriping shows that 19311-37-6 is playing an increasingly important role.
Reference£º
Patent; PFIZER INC.; ASPNES, Gary Erik; DIDIUK, Mary Theresa; GUZMAN-PEREZ, Angel; MAGUIRE, Robert John; WO2011/158149; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem