With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112372-15-3,Furo[2,3-c]pyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
A solution of tert-butyl 4-[6- (aminomethyl)pyridine-3 -sulfonyl]piperidine-1-carboxylate (90 mg, 0 25 mmol), furo[2,3-c]pyridine-2-carboxylic acid (49.5 mg, 0.30 mmol, 1 .20 equiv), EDCI (96 mg, 0.49 mmol), HOBt (5 1 mg, 0.37 mmol), and triethylamine (77 mg, 0.75 mmol, 3.01 equiv, 98%) in DMF (1 mL) was stirred overnight at rt. The reaction was then quenched by the addition of 1 0 mL of water and the resulting solution was extracted with 3×20 mL of ethyl acetate. The combined organic layers was washed with 2×20 mL of water, dried over anhydrous sodium sulfate, and concentrated under vacuum to give 1 04 mg (84%) of tert-butyl 4-[6-([furo[2,3-c]pyridin-2- ylformamido]methyl)pyridine-3-sulfonyl]piperidine-1-carboxylate as a yellow oil. LC MS (Method F, ESI): RT = 1 . 1 5 min, w z = 501 .0 [M+H], 112372-15-3
As the paragraph descriping shows that 112372-15-3 is playing an increasingly important role.
Reference£º
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; GOSSELIN, Francis; YUEN, Po-Wai; ZAK, Mark; ZHENG, Xiaozhang; WO2013/127267; (2013); A1;,
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