Day: November 12, 2020

22929-52-8, Dihydrofuran-3(2H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) 3-Hydroxy-3-vinyltetrahydrofuran Obtained from tetrahydrofuran-3-one (J. Org. Chem., 1989, 54, 1249) and vinylmagnesium bromide, by a procedure similar to that described in Example 5(a), as an oil. Rf 0.45 (SS 7). delta(CDCl3): 1.90 (1H, br s), 1.92-2.20 (2H, m), 3.62-3.78 (2H, m), 3.92-4.10 (2H, m), 5.20 (1H, d), 5.44 (1H, d), 5.95-6.08 (1H, dd). HRMS: m/z 114.068.

22929-52-8, The synthetic route of 22929-52-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US5607960; (1997); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.

5061-21-2, General procedure: To a stirred mixture of thiols 12a-12k (100 mmol) and K2CO3(27.64 g, 200 mmol) in DMF (120 mL) at room temperaturewas added alpha-bromobutyrolactone (10, 14.85 g, 90 mmol), andthe resulting mixture was stirred at room temperature until thecompletion of reaction as indicated by TLC analysis (typicallywithin 12 h).The reaction mixture was poured into ice-water (400 mL),and the mixture thus obtained was extracted with CH2Cl2 (3 ¡Á100 mL). The combined extracts were washed successively with10% aqueous Na2CO3 (2 ¡Á 100 mL) and 5% brine (3 ¡Á 100 mL),dried over anhydrous Na2SO4 and evaporated on a rotary evaporator to aord a residue, which was purifed by columnchromatography to yield 13a-13k after trituration withEtOAc/n-hexane if the product was a solid.

As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.

Reference£º
Article; Zhang, Xiansheng; Wu, Jingwei; Liu, Yuqiang; Xie, Yafei; Liu, Changying; Wang, Jianwu; Zhao, Guilong; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 7; (2017); p. 799 – 811;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.24 g, 1.75 mmol) And triethylamine (0.18 g, 1.75 mmol) Was added to chloroform (amylene added product) (8 mL). To the mixture, 5- (5,6,7,8-tetrahydronaphthalen-2-yl) oxymethyl isoxazole-3-carboxylic acid (0.40 g, 1.46 mmol) at room temperature, 1-Hydroxybenzotriazole (0.02 g, 0.18 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.34 g, 1.75 mmol) After stirring for 5 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain the compound represented by the following formula Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (5,6,7,8-tetrahydronaphthalen-2-yl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (239)) 0.40 g was obtained., 184950-35-4

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.124391-75-9,(S)-(Tetrahydrofuran-3-yl)methanol,as a common compound, the synthetic route is as follows.

TETRAHYDRO-3-FURAN methanol 65 (0.50 g, 4.9 mmol) was dissolved in dry DCM (30 mL) and triethylamine (1.06 mL, 8.8 mmol, 1.8 equiv) was added to the solution via syringe under N2 with stirring. The solution was cooled to 0 ¡ãC and METLIANESULFONYL chloride 63 (0.68 mL, 8.8 mmol, 1.8 equiv) added dropwise via syringe. The resultant solution was allowed to warm to RT and stirred at RT for 36 h. The solvent was then removed in vacuo. The residue was dissolved in fresh DCM and water (25 mL) added to the solution. The solution was then extracted with DCM. The DCM extracts were washed with brine, and the brine back-extracted with DCM. The combined DCM extracts were then reduced in vacuo to yield a yellow oil (66,0. 88 g, quantitative)., 124391-75-9

As the paragraph descriping shows that 124391-75-9 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED; REGA FOUNDATION; WO2004/96813; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112372-15-3,Furo[2,3-c]pyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 4-[6- (aminomethyl)pyridine-3 -sulfonyl]piperidine-1-carboxylate (90 mg, 0 25 mmol), furo[2,3-c]pyridine-2-carboxylic acid (49.5 mg, 0.30 mmol, 1 .20 equiv), EDCI (96 mg, 0.49 mmol), HOBt (5 1 mg, 0.37 mmol), and triethylamine (77 mg, 0.75 mmol, 3.01 equiv, 98%) in DMF (1 mL) was stirred overnight at rt. The reaction was then quenched by the addition of 1 0 mL of water and the resulting solution was extracted with 3×20 mL of ethyl acetate. The combined organic layers was washed with 2×20 mL of water, dried over anhydrous sodium sulfate, and concentrated under vacuum to give 1 04 mg (84%) of tert-butyl 4-[6-([furo[2,3-c]pyridin-2- ylformamido]methyl)pyridine-3-sulfonyl]piperidine-1-carboxylate as a yellow oil. LC MS (Method F, ESI): RT = 1 . 1 5 min, w z = 501 .0 [M+H], 112372-15-3

As the paragraph descriping shows that 112372-15-3 is playing an increasingly important role.

Reference£º
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; GOSSELIN, Francis; YUEN, Po-Wai; ZAK, Mark; ZHENG, Xiaozhang; WO2013/127267; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- [3- (4-chlorophenyl) propyl] isoxazole-3-carboxylic acid (0.7 8 g, 2.9 mmol) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.60 g, 4.4 mmol), Triethylamine (0.44 g, 4.4 mmol) And 1-hydroxybenzotriazole (0.04 g, 0.3 mmol) Was added to a mixed solvent of chloroform (amylene addition product) (4 mL) and tetrahydrofuran (4 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.67 g, 3.5 mmol) was added at room temperature, After stirring overnight at room temperature, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, Washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (3- (4-chlorophenyl) propyl) isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (25 2)) 0.78 g was obtained.

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0

The reactor was charged with 1 g of HSL ¡¤ HCl, 40 g of methanol and 0.05 g of Pt (5) / Ac, followed by NO / N2 (15 atm, 1: 1 (v / v) As above, additional H2 (6.5 atm) was added and the desmethylation reaction of HSL.HCl was performed. The product was partially recovered and the components were analyzed. The results are shown in Table 8 below.

As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (1.71 g, 12.4 mmol) and triethylamine (1.89 g, 18.7 mmol) were added to tetrahydrofuran (10 mL). To the mixture solution was added (E)-2-octenoic acid chloride (1.00 g, 6.22 mmol) under ice cooling, then the mixture was stirred at room temperature for 4 hours. Thereafter, water was added to the reaction mixture, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with an aqueous solution of sodium bicarbonate, and dried over anhydrous sodium sulfate, then filtered, and the filtrate was concentrated under reduced pressure. The residue was applied to a silica gel column chromatography, to obtain 1.25 g of (E)-N-(tetrahydrofuran-3-ylmethyl)-2-octenamide (hereinafter, described as Compound (1) of the present invention) represented by the following formula.1H-NMR (CDCl3, TMS) delta (ppm): 0.88 (t, 3H), 1.22-1.38 (m, 4H), 1.40-1.48 (m, 2H), 1.58-1.68 (m, 1H), 2.00-2.09 (m, 1H), 2.17 (dq, 2H), 2.46-2.57 (m, 1H), 3.30-3.38 (m, 2H), 3.55 (dd, 1H), 3.74 (dd, 1H), 3.82 (dd, 1H), 3.89 (td, 1H), 5.65 (br s, 1H), 5.75 (dt, 1H), 6.84 (dt, 1H)

184950-35-4, As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company Limited; IHARA, Hideki; AWANO, Tomotsugu; OHSHITA, Jun; MATSUO, Noritada; EP2813493; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111769-27-8,(R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate,as a common compound, the synthetic route is as follows.

To a solution of (2,6-dimethylpyridin-4-yl)methyl 4-nitrophenyl carbonate (Intermediate 2;235 mg, 0.78 mmol) in DMF (5 mL) was added DIPEA (400 muL, 2.3 mmol), (R)- tetrahydrofuran-3 -amine toluenesulfonate (221 mg, 0.85 mmol) and DMAP (10 mg, catalytic). The reaction mixture was stirred overnight and then concentrated in vacuo. The residue was dissolved in EtOAc (25 mL), washed with IM aq Na2CO3 solution (5 x 25 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (5 mL) and treated with 2M HCl in Et2O (0.5 mL, 1.0 mmol) to give a precipitate. The – -solvent was removed by decantation and the precipitate was dried in vacuo to give (2,6- dimethylpyridin-4-yl)methyl (3R)-tetrahydrofuran-3-ylcarbamate hydrochloride (102 mg, 46%) as a white solid.Analytical HPLC: purity 99.3% (System A, Rtau = 3.03 min); Analytical LCMS: purity 100% (System E, Rtau = 4.59 min), ES+: 251.4 [MH]+; HRMS calcd for Ci3Hi8N2O3: 250.1317, found 250.1330.

111769-27-8, The synthetic route of 111769-27-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOVITRUM AB (PUBL); WO2009/147216; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17347-61-4, Example 15: Preparation of 2,2-dimethyl-4-oxo-4-(((lR,3aS,5aR,5bR,7aR,9S,l laR,l lbR, 13aR,13bR)-5a,5b,8,8,l la-pentamethyl-3a-((S)-2-(l-methyl-4-phenyl-lH-imidazol-2-yl) pyrrolidine- l-carbonyl)-l-(prop-l-en-2-yl)icosahydro-lH-cyclopentaralchrysen-9-yl)oxy) butanoic acid:2,2-Dimethylsuccinic anhydride (385 mg, 3.0 mmol) was added to a stirred solution of ((lR,3aS,5aR,5bR,7aR,9S,l laR,l lbR,13aR,13bR)-9-hydroxy-5a,5b,8,8,l la-pentamethyl- l-(prop-l-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysen-3a-yl)((S)-2-(l-methyl-4-phenyl- lH-imidazol-2-yl)pyrrolidin-l-yl)methanone (Example 1-step 2, 500 mg, 0.75 mmol) and DMAP (183 mg, 1.49 mmol) in pyridine (8 ml) at room temperature and heated at 90¡ãC for about 24 hours. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with dichloromethane, washed with 20percent HCl and brine solution. The residue was dried over Na2S04, filtered, the solvent was evaporated under reduced pressure and purified on silica gel column (100-200 mesh, elution 36-40percent ethyl acetate/hexanes) to afford the title compound (240 mg, Yield: 40percent) as an off white solid. H1 NMR (DMSO-D6, 300 MHz): delta 12.15 (s, 1H), 7.64 (d, J = 7.5 Hz, 2H), 7.42 (s, 1H), 7.27 (t, J = 7.5 Hz, 2H), 7.11 (t, J = 7.5, 1H), 5.11 (m, 1H), 4.50 (s, 1H), 4.43 (s, 1H), 4.35 (m, 1H), 3.85 (m, 1H), 3.68 (s, 3H), 3.65 (m, 1H), 2.75 (m, 1H), 2.10-2.60 (m, 6H), 0.70-2.0 (m, 48H); Mass (ESI): 794.55 [M+H]+; HPLC: 92.60percent.

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; ADULLA, Panduranga Reddy; GAZULA LEVI, David Krupadanam; BAMMIDI, Eswara Rao; KOTHAKAPU, Ranga Reddy; (78 pag.)WO2016/1820; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem