16874-33-2, Tetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Stage II: Preparation of N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino]propyl]tetrahydrofuran-2-carboxamide (Alfuzosin); Ethyl chloroformate (22.35 g, 0.206 mol) was added to a mixture of tetrahydrofuran-2- carboxylic acid (23.90 g, 0.206 mol), and triethylamine (20.80 g, 0.206 mol) in methylene dichloride (300 ml) at 0-50C. The stirring was continued for 30 min at 0-50C to complete the formation of mixed anhydride. To this, mixture of N]-(4-amino-6,7- dimethoxyquinazolin-2-yl)-Ni-methylpropane-l,3-diamine (50 g, 0.172 mol) in methylene dichloride (200 ml) was added at 0-50C and stirring was continued for additional 1 hr at 0-50C to complete the reaction. Thereafter, water was added to the reaction mass and pH was adjusted to 4.0-4.5. The organic layer was discarded and the pH of the aqueous layer was raised to 10-10.5 with aqueous sodium hydroxide. The aqueous layer was extracted with methylene dichloride and the organic extract was concentrated to remove methylene dichloride. The concentrated mass was stirred with acetone to afford Alfuzosin. The product was filtered and dried under vacuum. Yield: 50 g (75percent of theory). HPLC purity: 99.97percent.
16874-33-2, As the paragraph descriping shows that 16874-33-2 is playing an increasingly important role.
Reference£º
Patent; AUROBINDO PHARMA LIMITED; WO2007/74364; (2007); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem