86087-24-3,86087-24-3, (R)-Tetrahydrofuran-3-ol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (3R)-tetrahydrofuran-3-o[ (18 g, 204 mmo[), TEA (42.7 m[, 306 mmo[), trimethy[amine hydroch[oride (1.95 g, 20.4 mmo[) in DCM (626 mL) was stirred at RT for 20 mi 4-methy[benzenesu[fony[ ch[oride (42.8 g, 225 mmo[) was added andthe reaction mixture stirred at RT unti[ comp[ete conversion. To the reaction mixture N,N-Dimethy[ethy[enediamine (26.4 m[, 245 mmo[) was added and stirred for 30 mm to consume the unreacted 4-methy[benzenesu[fony[ ch[oride. Water was added and the mixture was extracted with DCM (3x). The combined organic [ayers were evaporated to dryness under reduced pressure and the residue was purifiedby co[umn chromatography (si[ica ge[, hexane/ EE/ DCM/ MeOH gradient) to give41.0 g (83% yie[d) of the tit[e compound.1H NMR (400 MHz, DMSO-d6) oe [ppm] 1.79 – 1.95 (m, 1 H) 2.08 (dtd, 1 H) 2.43 (5, 3 H) 3.57 – 3.81 (m, 4 H) 5.12 (ddt, 1 H) 7.49 (d, 2 H) 7.81 (d, 2 H).
As the paragraph descriping shows that 86087-24-3 is playing an increasingly important role.
Reference£º
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem