453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Anhydrous tetrahydrofuran (1OmI) was added to sodium hydride as a 60% dispersion in mineral oil (312 mg, 1.1 eq, 7.8 mmol.) in a flask fitted with a condenser, a nitrogen inlet and a bubbler. While stirring, 3- hydroxytetrahydrofuran (624 mg, 7.09 mmol, 1 eq) was added slowly and the mixture was left to stir at room temperature for 10-15 minutes. To the solution of sodium alkoxide in THF was added 2-fluoronitrobenzene (1 g, 7.09 mmol, 1 eq). The reaction mixture was heated to reflux with stirring for 4.5 hours. The reaction was then allowed to cool down to room temperature, then water (20ml) was added to the reaction mixture. The resulting mixture was extracted three times with ethyl acetate (20 ml), the organics dried over sodium sulfate, filtered and the filtrate evaporated to dryness to give the title compound 3-(2-nitro-phenoxy)- tetrahydrofuran as an orange oil (1.48 g, 7.07 mmol, 100%). 1H NMR indicates desired compound in ca. 90% purity.
453-20-3, The synthetic route of 453-20-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DEVELOGEN AKTIENGESELLSCHAFT; WO2007/59905; (2007); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem